Results 51 to 60 of about 9,208,925 (289)

Interferon Regulatory Factors in Heart [PDF]

Hypertension, 2014
See related article, p 713–722 Cardiac hypertrophy and pathological remodeling are hallmarks of cardiomyopathy associated with many pathological stressors, such as mechanic overload, oxidative injury, hormonal stimulation, or viral infection. Transcriptional regulation is key to this process, involving well-established transcription factors, such as ...
Haipeng, Sun, Yibin, Wang
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Identification of the DNA sequence interacting with Kaposis sarcoma-associated herpesvirus viral interferon regulatory factor 1 [PDF]

, 2007
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal ...
Yoo, Seung-Min, Lee, Daeyoup, Lee, Myung-Shin, Jeong, Kwi Wan, Choe, Joonho, Seo, Taegun, Park, Junsoo   +6 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found

BMC Biology
Background Interferon regulatory factors (IRFs) are a family of transcription factors with important functions in immunity. The genomes of most vertebrates encode ten IRF genes.
Lenka Ungrová, Josef Geryk, Marina Kohn, Dana Kučerová, Veronika Krchlíková, Tomáš Hron, Vladimír Pečenka, Petr Pajer, Eliška Gáliková, Ľubomíra Pecnová, Bernd Kaspers, Jiří Hejnar, Jiří Nehyba, Daniel Elleder   +13 more
doaj   +1 more source

siRNAs to Knockdown Antiviral Chemokine-related Genes in FRhK-4 Cells

Journal of Food Protection, 2023
The objective of this study was to generate small interfering RNA (siRNA) to knockdown antiviral chemokine-related genes in fetal rhesus monkey kidney (FRhK-4) cells.
Eunyoung Park, Yoonjeong Yoo, Sangeun Park, Changsun Choi, Yohan Yoon   +4 more
doaj   +1 more source

Transcriptional control of metabolism by interferon regulatory factors. [PDF]

Nat Rev Endocrinol
Interferon regulatory factors (IRFs) comprise a family of nine transcription factors in mammals. IRFs exert broad effects on almost all aspects of immunity but are best known for their role in the antiviral response. Over the past two decades, IRFs have been implicated in metabolic physiology and pathophysiology, partly as a result of their known ...
Ahmad Z, Kahloan W, Rosen ED.
europepmc   +3 more sources

Interferon regulatory factor 5 and autoimmune lupus [PDF]

Expert Reviews in Molecular Medicine, 2013
Systemic lupus erythematosus (SLE) is a severe multi-system autoimmune disease, whereas interferon regulatory factor (IRF) 5 belongs to the family of transcription factors that modulate immune system activities. Recently, many lines of investigations suggested that IRF5 gene polymorphisms are closely associated with the disease onset of SLE.
Xu, W-D, Pan, H-F, Xu, Y, Ye, D-Q
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases

Frontiers in Immunology
Dysregulation of type I interferon (IFN-I) signaling has been implicated in the pathogenesis of multiple systemic autoimmune diseases, including systemic lupus erythematosus, Sjögren’s syndrome, and rheumatoid arthritis.
Kailai Panlu, Yihan Wang, Xinchao Zhu, Zhiting Lin, Ting Fang, Xinyi Yao, Zhimin Xie, Xinchang Wang   +7 more
doaj   +1 more source