Results 41 to 50 of about 9,208,925 (289)
IRF1 (interferon regulatory factor 1) [PDF]
, 2008 Review on IRF1 (interferon regulatory factor 1), with data on DNA, on the protein encoded, and where the gene is ...
Palladinetti, P +5 more
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Structural insights into interferon regulatory factor activation [PDF]
Cellular Signalling, 2010 The interferon regulatory factors (IRFs) play important roles in development of the immune system and host defense. Recent crystallographic and biochemical studies have provided insights into the mechanism of activation of IRFs by phosphorylation. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of ...
Weijun, Chen, William E, Royer
openaire +2 more sources
, 2009 Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the beta-interferon gene and many interferon-stimulated genes. Two well-studied members of this family, IRF-1 and
Stein, Janet L. +3 more
core +1 more source
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda +24 more
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Interferon regulatory factors in human lupus pathogenesis [PDF]
Translational Research, 2011 Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that results from both genetic predisposition and environmental factors. Many lines of investigation support interferon alpha (IFN-α) as a causal agent in human lupus, and high levels of serum IFN-α are a heritable risk factor for SLE. Interferon regulatory factors (IRFs) are
Rafah, Salloum, Timothy B, Niewold
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IRF4 (interferon regulatory factor 4) [PDF]
, 2009 Review on IRF4 (interferon regulatory factor 4), with data on DNA, on the protein encoded, and where the gene is ...
Rasi, S, Gaidano, G
core +1 more source
Interferon Regulatory Factor 1 in Mycobacterial Infection [PDF]
Microbiology and Immunology, 2002 AbstractIn order to understand the role of IRF‐1 in the development of murine tuberculosis in vivo, IRF‐1 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. These knockout mice developed multifocal necrotic lesions in the lung, liver and spleen tissues and died of ...
Hiroyuki, Yamada +2 more
openaire +2 more sources
Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection [PDF]
, 2012 Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE).
Yamaguchi, Naohiro +7 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape [PDF]
, 2003 Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1
Bossert, Birgit
core +1 more source