Results 21 to 30 of about 9,208,925 (289)
Aquaculture Reports, 2022 Interferon regulatory factor (IRF) 3 and IRF7 are important innate immune-related genes that induce type I interferon (IFN). In this study, PmIRF3 and PmIRF7 were identified from red sea bream (Pagrus major) infected by red sea bream iridovirus (RSIV ...
Min-Soo Joo +8 more
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Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
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New Microbes and New Infections, 2021 The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19), resulting in acute respiratory disease, is a worldwide emergency.
I. di Bari +13 more
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Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.) +3 more
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Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren’s syndrome [PDF]
International Journal of OphthalmologyAIM: To investigate the expression of interferon regulatory factors (IRFs) in peripheral blood mononuclear cells (PBMCs) of patients with Sjögren's syndrome-related dry eye (SSDE) and to explore their correlation with clinical features, dendritic cell ...
Jiao Wang +6 more
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The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
Frontiers in Immunology, 2011 Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) is a large double stranded DNA gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castlemen’s disease.
Blossom eDamania, Sarah R Jacobs
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Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
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Neural Regeneration Research, 2017 Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function.
Hsiao-Huei Chen, Alexandre F. R. Stewart
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Potential Therapeutic Value of the STING Inhibitors
Molecules, 2023 The stimulator of interferon genes (STING) is a critical protein in the activation of the immune system in response to DNA. It can participate the inflammatory response process by modulating the inflammation-preferred translation program through the ...
Shangran Zhang +3 more
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The growing family of interferon regulatory factors
Cytokine & Growth Factor Reviews, 1997 Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well ...
H, Nguyen, J, Hiscott, P M, Pitha
openaire +2 more sources