The role of interferon regulatory factors in atherosclerosis [PDF]
Frontiers in Cardiovascular MedicineCardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, largely driven by the progression of atherosclerotic plaques.
Yingsong Wang +8 more
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Interferons and Interferon Regulatory Factors in Malaria [PDF]
Mediators of Inflammation, 2014 Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually.
Sin Yee Gun +3 more
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Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization [PDF]
Mediators of Inflammation, 2013 The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their ...
Roman Günthner, Hans-Joachim Anders
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Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma [PDF]
Frontiers in Oncology, 2023 BackgroundInterferon regulatory factors (IRFs) played complex and essential roles in progression, prognosis, and immune microenvironment in clear cell renal cell carcinoma (ccRCC).
Hao Pan +3 more
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Interferon regulatory factors: the next prospective targets for tissue ischemia–reperfusion injury? [PDF]
Frontiers in ImmunologyIschemia–reperfusion injury (IRI) represents a severe form of tissue or organ damage that occurs spontaneously and passively during the reperfusion process, following abrupt pathophysiological disturbances in the internal milieu.
Jie Xie +8 more
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The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies [PDF]
Frontiers in Cell and Developmental BiologyInterferon regulatory factors (IRFs) constitute a family of transcription factors that orchestrate innate and adaptive immune responses, metabolic regulation, and cellular homeostasis.
Jie Huang +5 more
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Comparative analysis of the impact of interferon regulatory factors on basal and induced interferon and interferon stimulated gene expression in human and canine keratinocytes [PDF]
Frontiers in ImmunologyIntroductionKeratinocytes are key barrier cells able to mount a robust interferon (IFN) antiviral response to defend against infection in the skin. Similar to humans, dogs spontaneously develop skin disorders associated with dysregulation of IFN immunity
Sarah Quinlan +3 more
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Genome-Wide Transcriptional Roles of KSHV Viral Interferon Regulatory Factors in Oral Epithelial Cells [PDF]
VirusesThe viral interferon regulatory factors (vIRFs) of KSHV are known to dysregulate cell signaling pathways to promote viral oncogenesis and to block antiviral immune responses to facilitate infection.
Seung Jin Jang +6 more
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Interferon Regulatory Factors in Alcohol-Associated Liver Disease: Cell-Type Programs, Danger Signaling, and Therapeutic Opportunities [PDF]
Current Issues in Molecular BiologyAlcohol-associated liver disease (ALD) contributes substantially to the global burden of cirrhosis and liver-related mortality, driven by ethanol metabolism, oxidative stress, and dysregulated immune signaling.
Haibo Dong, Wei Guo, Zhanxiang Zhou
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A Biomimetic In Vitro Model of the Pro-Inflammatory Microenvironment Recapitulates Type I/II Interferon Signaling and Refractory Acute Monocytic Leukemia [PDF]
BiologyPreclinical drug development suffers from a persistent translational gap, as conventional animal models fail to reproduce the human immune response, contributing to high attrition rates of drug candidates in clinical trials.
Kirill Krasnov +9 more
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