Results 31 to 40 of about 9,208,925 (289)

Phosphorylation of interferon regulatory factor 9 (IRF9)

Molecular Biology Reports, 2023
IRF9 is a transcription factor that mediates the expression of interferon-stimulated genes (ISGs) through the Janus kinase-Signal transducer and activator of transcription (JAK-STAT) pathway. The JAK-STAT pathway is regulated through phosphorylation reactions, in which all components of the pathway are known to be phosphorylated except IRF9. The enigma
Alvin Paul, Mohd Nazri Ismail, Thean Hock Tang, Siew Kit Ng   +3 more
openaire   +2 more sources

The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Gastroenterology Insights, 2022
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases.
Chunye Zhang, Shuai Liu, Ming Yang
doaj   +1 more source

Optineurin regulates the interferon response in a cell cycle-dependent manner. [PDF]

PLoS Pathogens, 2015
Viral invasion into a host is initially recognized by the innate immune system, mainly through activation of the intracellular cytosolic signaling pathway and coordinated activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF ...
Pierre Génin, Frédérique Cuvelier, Sandrine Lambin, Josina Côrte-Real Filipe, Elodie Autrusseau, Christine Laurent, Emmanuel Laplantine, Robert Weil   +7 more
doaj   +1 more source

Activation and Function of Interferon Regulatory Factor 5

Journal of Interferon & Cytokine Research, 2015
Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. Upon induction of immune signaling pathways, IRF5 undergoes post-translational modifications such as phosphorylation and ubiqutination, which are believed to ...
Ryzhakov, G, Eames, H, Udalova, I
openaire   +2 more sources

Transcriptomic and Epigenetic Alterations in Dendritic Cells Correspond With Chronic Kidney Disease in Lupus Nephritis

Frontiers in Immunology, 2019
Systemic lupus erythematosus (SLE) is a serious autoimmune disease with variety of organ manifestations. The most dreadful one, affecting the majority of SLE patients, is kidney manifestation—lupus nephritis (LN).
Anna Wardowska, Anna Wardowska, Michał Komorniczak, Barbara Bułło-Piontecka, M. Alicja Dȩbska-Ślizień, Michał Pikuła, Michał Pikuła   +6 more
doaj   +1 more source

CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]

, 2010
Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA, Johansson, C, Cecilia Johansson, Tregoning, John S, Jürgen Schwarze, Atabani, Sowsan F, Lee, Debbie C P, Atabani, SF, Lee, DC, Harker, James A E, Peter J. M. Openshaw, Schwarze, J, Harker, JAE, James A. E. Harker, Openshaw, Peter J M, Tregoning, JS, Lee, DCP, Johansson, Cecilia, John S. Tregoning, Openshaw, PJ, Schwarze, Jürgen, Openshaw, PJM, Debbie C. P. Lee, Sowsan F. Atabani   +23 more
core   +1 more source

Identification of Proteins Immunologically Related to Interferon Regulatory Factor–1 That Bind with Interferon Regulatory Factor Element [PDF]

The Journal of Infectious Diseases, 2006
Interferon regulatory factor (IRF)-1 expression was surveyed in nontransformed and oncogene-transformed mouse fibroblasts, using Western immunoblot with an IRF-1-specific antiserum, to examine possible differences resulting from cellular transformation. Ten additional proteins that reacted with the IRF-1 antibody and that underwent specific competition
Sara, Contente, Frank A, Attard, Robert M, Friedman   +2 more
openaire   +2 more sources

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +2 more sources

Inducible Processing of Interferon Regulatory Factor-2 [PDF]

Molecular and Cellular Biology, 1992
PRDI-BFc and PRDI-BFi are proteins that bind specifically to a regulatory element required for virus induction of the human beta interferon (IFN-beta). PRDI-BFc is a constitutive binding activity, while the PRDI-BFi binding activity is observed only after cells are treated with inducers such as virus or poly(I).poly(C) plus cycloheximide or in some ...
V J, Palombella, T, Maniatis
openaire   +2 more sources

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria.

PLoS Pathogens, 2016
CD4 T cell-dependent antibody responses are essential for limiting Plasmodium parasite replication and the severity of malaria; however, the factors that regulate humoral immunity during highly inflammatory, Th1-biased systemic infections are poorly ...
Ryan A Zander, Jenna J Guthmiller, Amy C Graham, Rosemary L Pope, Bradly E Burke, Daniel J J Carr, Noah S Butler   +6 more
doaj   +1 more source