Results 181 to 190 of about 332,508 (311)

Interferon-Type-I Response and Autophagy Independently Regulate Radiation-Induced HLA-Class-I Molecule Expression in Lung Cancer. [PDF]

Curr Issues Mol Biol
Xanthopoulou ET, Lamprou I, Koukourakis IM, Mitrakas AG, Michos GD, Polyzoidou A, Antoniadis FG, Giatromanolaki A, Koukourakis MI.   +8 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells

, 2011
Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
core  

SARS-CoV-2 promote autophagy to suppress type I interferon response

Signal Transduction and Targeted Therapy, 2021
Xianfeng Hui, Linliang Zhang, Lei Cao, Kun Huang, Ya Zhao, Yufei Zhang, Xi Chen, Xian Lin, Mingzhou Chen, Meilin Jin   +9 more
doaj   +1 more source

Detection of autoantibodies against Interferon Type I in patients with autochthonous West Nile Virus encephalitis. [PDF]

Brain Behav Immun Health
Braune J, Pechstein L, Meisel C, Meyer T, Melchert J, Corman VM, Franke C, Schneider T.   +7 more
europepmc   +1 more source

Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts. [PDF]

Cell Death Dis, 2018
Rizzo M, Beffy P, Del Carratore R, Falleni A, Pretini V, D'Aurizio R, Botta A, Evangelista M, Stoccoro A, Coppedè F, Furling D, Simili M.   +11 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans. [PDF]

Nat Immunol
Keramati F, Leijte GP, Bruse N, Grondman I, Habibi E, Ruiz-Moreno C, Megchelenbrink W, Peters van Ton AM, Heesakkers H, Bremmers ME, van Grinsven E, Tesselaar K, van Staveren S, van der Velden WJ, Preijers FW, Te Pas B, van de Loop R, Gerretsen J, Netea MG, Stunnenberg HG, Pickkers P, Kox M.   +21 more
europepmc   +1 more source

Dumbbell‐Structured Plasmonic‐Enhanced Optical Nanoprobes Boosting Photo‐Magnetic‐Acoustic Multimodal Imaging‐Guided Photodynamic‐Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An, Yuanzhi Shao, Botao Gao, Jinchang Yin   +12 more
wiley   +1 more source

Investigating interferon type I responses in patients with suspected giant cell arteritis and polymyalgia rheumatica. [PDF]

Clin Exp Immunol
van Nieuwland M, Mulder AHL, Colin EM, Alves C, van Bon L, Brouwer E.   +5 more
europepmc   +1 more source