Results 11 to 20 of about 306,829 (312)
Bunyaviruses and the Type I Interferon System [PDF]
Viruses, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Friedemann Weber
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Type I Interferon in Human Autoimmunity [PDF]
Frontiers in Immunology, 2014 The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response ...
Timothy B. Niewold
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Immunological Reviews, 2023 SummaryType I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at
Peter Holicek +6 more
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Type I interferon–related kidney disorders
Kidney International, 2022 Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral infections, autoimmunity (e.g., systemic lupus ...
Lodi, Lorenzo +7 more
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Type I Interferons in NeuroHIV [PDF]
Viral Immunology, 2019 Infection with Human Immunodeficiency Virus (HIV)-1 continues to cause HIV-associated neurocognitive disorders despite combined antiretroviral therapy. Interferons (IFNs) are important for any antiviral immune response, but the lasting production of IFNα causes exhaustive activation leading eventually to progression to AIDS.
Thaney, Victoria E, Kaul, Marcus
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Type-I interferons in atherosclerosis [PDF]
Journal of Experimental Medicine, 2019 The contribution of dyslipidemia and inflammation in atherosclerosis is well established. Along with effective lipid-lowering treatments, the recent success of clinical trials with anti-inflammatory therapies and the accelerated atherosclerosis in many autoimmune diseases suggest that targeting inflammation may open new avenues for the prevention and ...
Hung-Jen Chen +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We previously demonstrated that ischemically injured cardiomyocytes release cell‐free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses and ultimately exacerbating ...
Lina Lai +5 more
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Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis. [PDF]
PLoS ONE, 2015 Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I interferon-based therapy, implying that activation of type I interferon signaling affects the ...
Katharina J Miller +7 more
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Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
Frontiers in Immunology, 2021 Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells.
Megen C. Wittling +3 more
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Type I interferon induces cancer stem cells-mediated chemotherapy resistance
OncoImmunology, 2022 In a recent study in Nature Immunology, Musella et al. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic
Mara De Martino, Claire Vanpouille-Box
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