Results 11 to 20 of about 5,005 (167)

Cloning of human Type I interferon cDNAs

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023
In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
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Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

Viruses, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago   +7 more
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Evasion of Type I Interferon by SARS-CoV-2

Cell Reports, 2020
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening
Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D. Menachery, Ricardo Rajsbaum, Pei-Yong Shi   +8 more
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Insights Into Type I and III Interferons in Asthma and Exacerbations

Frontiers in Immunology, 2020
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich, Danielle Antos, Natalie R. Melton, John F. Alcorn, Michelle L. Manni   +4 more
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Type I interferon: potential therapeutic target for psoriasis? [PDF]

PLoS ONE, 2008
BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation.
Yihong Yao, Laura Richman, Chris Morehouse, Melissa de los Reyes, Brandon W Higgs, Anmarie Boutrin, Barbara White, Anthony Coyle, James Krueger, Peter A Kiener, Bahija Jallal   +10 more
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The Role of Interferons in the Pathogenesis of Sjögren’s Syndrome and Future Therapeutic Perspectives

Biomolecules, 2021
There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the pathogenesis of different systemic autoimmune diseases, including primary Sjögren’s syndrome (pSS).
Nicoletta Del Papa, Antonina Minniti, Maurizio Lorini, Vincenzo Carbonelli, Wanda Maglione, Francesca Pignataro, Nicola Montano, Roberto Caporali, Claudio Vitali   +8 more
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Plasmacytoid Dendritic Cells Mediate Myocardial Ischemia/Reperfusion Injury by Secreting Type I Interferons

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We previously demonstrated that ischemically injured cardiomyocytes release cell‐free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses and ultimately exacerbating ...
Lina Lai, Aimee Zhang, Boris Yang, Eric J. Charles, Irving L. Kron, Zequan Yang   +5 more
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Antiproliferative Properties of Type I and Type II Interferon

Pharmaceuticals, 2010
The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz, Samuel Baron, Corey Balinsky, Angel Morrow, Kathryn C. Zoon   +4 more
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Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

Journal of Experimental & Clinical Cancer Research, 2021
Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation ...
Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris, Victor L. Thijssen   +15 more
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Phleboviruses and the Type I Interferon Response

Viruses, 2016
The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth, Friedemann Weber   +1 more
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