An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda +23 more
core +1 more source
Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C [PDF]
, 2012 Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial ...
Makowska, Zuzanna
core +1 more source
Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, 2018 Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist +2 more
doaj +1 more source
Defective interfering particles of parainfluenza virus subtype 5 and interferon induction [PDF]
, 2015 The innate immune response is the first line of defence against virus infection. Cells contain a diverse array of pathogen recognition receptors (PRRs) that are able to recognise multiple pathogen associated molecular patterns (PAMPS) that present ...
Short, John A. L.
core +2 more sources
Fine-Tuning of Type I Interferon Response by STAT3
Frontiers in Immunology, 2019 Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai +4 more
doaj +1 more source
The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]
PLoS Pathogens, 2011 Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang +6 more
doaj +1 more source
Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]
, 2013 Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294) +41 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Human interferon-ω: an underappreciated type I interferon
Frontiers in ImmunologyInterferon-ω (IFN-ω) is a member of the human type I interferon family that has historically been overshadowed by IFN-α and IFN-β. Recent human “natural perturbations”, most notably selective neutralization of IFN-ω by autoantibodies in life-threatening ...
Ruyue Chen
doaj +1 more source