Results 251 to 260 of about 1,888,881 (401)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Type I Interferons Promote Severe Disease in a Mouse Model of Lethal Ehrlichiosis [PDF]

, 2014
Yubin Zhang, Vinh Thai, Amanda F. McCabe, Maura Jones, Katherine C. MacNamara   +4 more
openalex   +1 more source

Association Between DNA Damage Response, Fibrosis and Type I Interferon Signature in Systemic Sclerosis [PDF]

, 2020
Nikolaos I. Vlachogiannis, Μαρία Παππά, Panagiotis A. Ntouros, Adrianos Nezos, Clio P. Mavragani, Vassilis L. Souliotis, Petros P. Sfikakis   +6 more
openalex   +1 more source

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Nature, 2009
Hiroki Ishikawa, Zhe Ma, G. Barber
semanticscholar   +1 more source

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Nature Immunology, 2020
Ioanna E Galani, N. Rovina, Vicky Lampropoulou, Vasiliki Triantafyllia, M. Manioudaki, Eleftherios Pavlos, E. Koukaki, P. Fragkou, Vasiliki Panou, V. Rapti, O. Koltsida, A. Mentis, N. Koulouris, S. Tsiodras, A. Koutsoukou, E. Andreakos   +15 more
semanticscholar   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Fanny Saidoune, Danyel Lee, Jérémy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie‐Anne Morren, Vivien Béziat, Shen‐Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean‐Laurent Casanova, Michel Gilliet, Ahmad Yatim   +18 more
openalex   +1 more source

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

, 2011
Tracy A. Briggs, Gillian Rice, Sarah B. Daly, Jill Urquhart, Hannah Gornall, Brigitte Bader‐Meunier, Kannan Baskar, Shankar Baskar, Véronique Baudouin, Michael W. Beresford, Graeme C. Black, Rebecca J. Dearman, Francis de Zegher, Emily Foster, Camille Françès, Alison R. Hayman, Emma Hilton, C Job-Deslandre, Muralidhar L. Kulkarni, Martine Le Merrer, Agnès Linglart, Simon C. Lovell, Kathrin Maurer, Lucile Musset, Vincent Navarro, Capucine Pïcard, Anne Puel, Frédéric Rieux‐Laucat, Chaim M. Roifman, Sabine Scholl‐Bürgi, Nigel Smith, Marcin Szynkiewicz, Alice Wiedeman, Carine Wouters, Leo Zeef, Jean‐Laurent Casanova, Keith B. Elkon, Anthony J. Janckila, Pierre Lebon, Yanick J. Crow   +39 more
openalex   +2 more sources

VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection [PDF]

, 2019
Sarah van Tol, Colm Atkins, Preeti Bharaj, Kendra N. Johnson, Adam Hage, Alexander N. Freiberg, Ricardo Rajsbaum   +6 more
openalex   +1 more source