Results 91 to 100 of about 419,392 (265)
Type I Interferons and Natural Killer Cell Regulation in Cancer
Frontiers in Immunology, 2017 Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types and have therefore been commonly used in clinical anticancer treatment.
L. Müller, P. Aigner, D. Stoiber
semanticscholar +1 more source
VirusesThe disruption of antiviral sensors and the evasion of immune defences by various tactics are hallmarks of EBV infection. One of the EBV latent gene products, LMP1, was shown to induce the activation of signalling pathways, such as NF-κB, MAPK (JNK, ERK1/
Petra Šimičić +3 more
doaj +1 more source
Animals, 2019 Heat stress significantly impacts the immunity and cytokine expression of chickens. However, the effects of embryonic thermal manipulation (TM) on cytokine expression in broiler chickens (broilers) is unclear.
Khaled M. M. Saleh +1 more
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Guarding the frontiers: the biology of type III interferons
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier ...
A. Wack +2 more
semanticscholar +1 more source
Frontiers in MedicineBackgroundMany studies have shown that cytokines play an important role in the pathogenesis of asthma, but their biological effects on asthma remain unclear.
Yansen Zheng +4 more
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Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications
Oncoimmunology, 2017 If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome.
M. Musella +4 more
semanticscholar +1 more source
CellsThreonine phosphorylation promotes inflammatory functions of STAT1 while restricting its interferon (IFN) signaling in innate immune responses. However, it remains unclear whether the restriction of STAT1-mediated IFN signaling conferred by threonine ...
Maha M. Elbrashy +3 more
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Multiple sclerosis: evidence and controversies [PDF]
Revista Ciencias de la Salud, 2006 Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with
Ángela María Gutiérrez-Álvarez
doaj
Interferon to PEG-Interferon: A Review
TAJ: Journal of Teachers Association, 1970 The interferons (IFNs) are group of naturally occurring cytokines that are secreted by cells of mammalian immune system when they are stimulated by viral, bacterial and other antigens. There are number of alpha IFNs available for treatment purposes. The two most commonly used α-2a and α-2b are made by recombinant technology. When interferon Alpha-2a is
Arm Saifuddin Ekram, MA Ahad, MA Alim
openaire +3 more sources
Optimal Therapy of Hepatitis C Dynamics and Sampling Based Analysis [PDF]
arXiv, 2011 We examine two models for hepatitis C viral (HCV) dynamics, one for monotherapy with interferon (IFN) and the other for combination therapy with IFN and ribavirin. Optimal therapy for both the models is determined using the steepest gradient method, by defining an objective functional which minimizes the infected hepatocyte levels, virion population ...
arxiv