Results 11 to 20 of about 418,590 (365)
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response.
Journal of Clinical Investigation, 2021 Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and -extrinsic mechanisms that determine the quality of antitumor immunity ...
Michelle von Locquenghien +2 more
semanticscholar +1 more source
How cells respond to interferons.
Annual Review of Biochemistry, 1998 Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct.
George R Stark +4 more
semanticscholar +1 more source
Inhibition of SARS–CoV-2 by type I and type III interferons
Journal of Biological Chemistry, 2020 The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic.
Ulrike Felgenhauer +7 more
semanticscholar +1 more source
The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway
Frontiers in Immunology, 2020 Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune response against multiple challenges like viral infections, autoimmune diseases, and cancer. While numerous anti-tumor activities have been described for IFNs,
Laura Martin-Hijano +5 more
doaj +1 more source
Antiviral Actions of Interferons
Clinical Microbiology Reviews, 2001 SUMMARY Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs.
C. E. Samuel
semanticscholar +1 more source
TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice
Cell Reports, 2016 Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection.
Lee Adam Wheeler +11 more
doaj +1 more source
Mediators of Inflammation, 1994 The in vitro action of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system.
S. B. Cheknev +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez +14 more
doaj +1 more source
Multiple sclerosis clinical decision support system based on projection to reference datasets
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022 Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch +13 more
wiley +1 more source
Canadian Journal of Infectious Diseases, 1994 The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs.
Scott Wadler
doaj +1 more source