Results 11 to 20 of about 105,445 (124)

The use of intranasal interferon for prevention and treatment of acute respiratory infections

Aktualʹnaâ Infektologiâ, 2021
Interferons are cytokines that are produced by immunocompetent cells in response to the invasion of an infectious factor. The most important biological effect of interferons used in clinical practice is their ability to nonspecifically inhibit viral ...
S.О. Kramarov, V.V. Yevtushenko
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The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family. [PDF]

PLoS ONE, 2009
BACKGROUND:Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone.
Brian A Fox, Paul O Sheppard, Patrick J O'Hara   +2 more
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Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Frontiers in Immunology, 2021
In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by a ...
Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina, Tiago da Silva Medina   +5 more
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Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

Frontiers in Immunology, 2021
In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited.
Miriam Mojzesz, Magdalena Widziolek, Mikolaj Adamek, Urszula Orzechowska, Piotr Podlasz, Tomasz K. Prajsnar, Niedharsan Pooranachandran, Anna Pecio, Anna Michalik, Win Surachetpong, Magdalena Chadzinska, Krzysztof Rakus   +11 more
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Interferons: Tug of War Between Bacteria and Their Host

Frontiers in Cellular and Infection Microbiology, 2021
Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs).
Noémie Alphonse, Noémie Alphonse, Ruth E. Dickenson, Charlotte Odendall   +3 more
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The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway

Frontiers in Immunology, 2020
Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune response against multiple challenges like viral infections, autoimmune diseases, and cancer. While numerous anti-tumor activities have been described for IFNs,
Laura Martin-Hijano, Laura Martin-Hijano, Laura Martin-Hijano, Bruno Sainz, Bruno Sainz, Bruno Sainz   +5 more
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TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

Cell Reports, 2016
Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection.
Lee Adam Wheeler, Radiana T. Trifonova, Vladimir Vrbanac, Natasha S. Barteneva, Xing Liu, Brooke Bollman, Lauren Onofrey, Sachin Mulik, Shahin Ranjbar, Andrew D. Luster, Andrew M. Tager, Judy Lieberman   +11 more
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Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes

Mediators of Inflammation, 1994
The in vitro action of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system.
S. B. Cheknev, Y. G. Ashmanova, A. D. Pritsker, O. L. Latysheva, F. I. Yershov, A. J. Kulberg   +5 more
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Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
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Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies

Canadian Journal of Infectious Diseases, 1994
The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs.
Scott Wadler
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