Results 11 to 20 of about 171,612 (313)

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

Cell Reports, 2016
Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection.
Lee Adam Wheeler, Radiana T. Trifonova, Vladimir Vrbanac, Natasha S. Barteneva, Xing Liu, Brooke Bollman, Lauren Onofrey, Sachin Mulik, Shahin Ranjbar, Andrew D. Luster, Andrew M. Tager, Judy Lieberman   +11 more
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Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes

Mediators of Inflammation, 1994
The in vitro action of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system.
S. B. Cheknev, Y. G. Ashmanova, A. D. Pritsker, O. L. Latysheva, F. I. Yershov, A. J. Kulberg   +5 more
doaj   +1 more source

The Roles of Amphibian (Xenopus laevis) Macrophages during Chronic Frog Virus 3 Infections

Viruses, 2021
Infections by Frog Virus 3 (FV3) and other ranavirus genus members are significantly contributing to global amphibian decline. The Xenopus laevis frog is an ideal research platform upon which to study the roles of distinct frog leukocyte populations ...
Muhammad Riadul Haque Hossainey, Amulya Yaparla, Kelsey A. Hauser, Tyler E. Moore, Leon Grayfer   +4 more
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Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies

Canadian Journal of Infectious Diseases, 1994
The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs.
Scott Wadler
doaj   +1 more source

A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer

Journal of Translational Medicine, 2018
Background Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach.
Daniel S. Green, Ana T. Nunes, Virginia David-Ocampo, Irene B. Ekwede, Nicole D. Houston, Steven L. Highfill, Hanh Khuu, David F. Stroncek, Seth M. Steinberg, Kathryn C. Zoon, Christina M. Annunziata   +10 more
doaj   +1 more source

Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy

Cells, 2023
Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a ...
Kornél Z. Varga, Katalin Gyurina, Ádám Radványi, Tibor Pál, László Sasi-Szabó, Haidong Yu, Enikő Felszeghy, Tamás Szabó, Tamás Röszer   +8 more
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An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

eLife, 2019
Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment.
Murilo Delgobo, Daniel AGB Mendes, Edgar Kozlova, Edroaldo Lummertz Rocha, Gabriela F Rodrigues-Luiz, Lucas Mascarin, Greicy Dias, Daniel O Patrício, Tim Dierckx, Maíra A Bicca, Gaëlle Bretton, Yonne Karoline Tenório de Menezes, Márick R Starick, Darcita Rovaris, Joanita Del Moral, Daniel S Mansur, Johan Van Weyenbergh, André Báfica   +17 more
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Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection

Frontiers in Immunology, 2021
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host ...
Krishna Latha, Katelyn F. Jamison, Wendy T. Watford   +2 more
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Extreme heterogeneity of influenza virus infection in single cells

eLife, 2018
Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus ...
Alistair B Russell, Cole Trapnell, Jesse D Bloom   +2 more
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IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

Journal of Innate Immunity, 2022
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead ...
Iris Aparici-Herraiz, Guillem Sánchez-Sánchez, Carlos Batlle, Pere Rehues, Martí López-Serrat, Lorena Valverde-Estrella, Jorge Lloberas, Antonio Celada   +7 more
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