Results 31 to 40 of about 105,445 (124)
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Frontiers in Immunology, 2020 Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer +4 more
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Immunity, Inflammation and Disease, 2018 Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford +6 more
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mBio, 2018 Phagocytic cells are the first line of innate defense against intracellular pathogens, and yet Toxoplasma gondii is renowned for its ability to survive in macrophages, although this paradigm is based on virulent type I parasites.
Sumit K. Matta +5 more
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Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis
eLife, 2021 Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen Rickettsia parkeri elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infection ...
Thomas P Burke +7 more
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Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity [PDF]
arXiv, 2022 Enveloped viral infections require fusion with cellular membranes for viral genome entry, occurring only following interaction of viral and cellular membranes allowing fusion pore formation, by which the virus accesses the cytoplasm. Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to
arxiv
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages
Journal of Innate Immunity, 2022 Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead ...
Iris Aparici-Herraiz +7 more
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Stratification of Systemic Lupus Erythematosus Patients Using Gene Expression Data to Reveal Expression of Distinct Immune Pathways [PDF]
, 2020 Systemic lupus erythematosus (SLE) is the tenth leading cause of death in females 15-24 years old in the US. The diversity of symptoms and immune pathways expressed in SLE patients causes difficulties in treating SLE as well as in new clinical trials.
arxiv +1 more source
mBio, 2022 As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion strategies, many of which are aimed at suppressing the production of type I interferons (IFNs).
Tate Tabtieng +4 more
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Vaccines, 2019 Interferons (IFNs) play central roles in establishing innate immunity and mediating adaptive immunity against multiple pathogens. Three known types of IFNs identify their cognate receptors, initiate cascades of signalling events and eventually result in ...
Diwakar Santhakumar +2 more
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Treatment of hepatitis C virus infection: From therapy with interferon to direct-acting antivirals
Iatreia, 2023 Hepatitis C virus (HCV) infection is a global public health concern. An estimated of 58 million people with chronic HCV infection are at risk of developing cirrhosis or hepatocellular carcinoma.
Laura Lopera +4 more
doaj +1 more source