Results 41 to 50 of about 171,612 (313)

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Interferons - A Review

Journal of Indian Academy of Oral Medicine and Radiology, 2005
Interferons are a family of proteins and glycoproteins that have a variety of biologic actions. Interferons were first discovered in 1957 and several clinical trials have been conducted since then to unravel the action and clinical applications of ...
Karthikeya Patil, V G Mahima, Shwetha Shetty   +2 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Multiple sclerosis: evidence and controversies [PDF]

Revista Ciencias de la Salud, 2006
Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with
Ángela María Gutiérrez-Álvarez
doaj  

PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA

Детские инфекции (Москва), 2018
Objective: study of immune status indices in newborns  in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns  with non-specific clinical symptoms were studied.
L. V. Kravchenko
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor in Multiple Sclerosis Disability: A Prospective Study

Brain Sciences
Multiple sclerosis (MS) is a demyelinating central nervous system disease that leads to neurological disability. Brain-derived neurotrophic factors (BDNFs) are neurotrophins involved in neurodegenerative disorders.
Vitalie Vacaras, Andreea-Cristina Paraschiv, Silvina Iluț, Cristiana Vacaras, Cristina Nistor, Gheorghe-Eduard Marin, Andra Maria Schiopu, Dorian-Traian Nistor, Ștefan Cristian Vesa, Dafin Fior Mureșanu   +9 more
doaj   +1 more source

Involvement of Epigenetics in the Pathogenesis, Testing and Management of Coronavirus Disease 2019 (COVID-19) Pandemic: A Narrative Review

Pharmaceutical and Biomedical Research, 2021
Background: There is an intense search for the Coronavirus Disease 19 (COVID-19) cure, to stem the spread and burden of the disease worldwide. Studies revealed that epigenetic modifications impact the pathogenesis of some COVID-19 cases, which can be ...
Tajudeen Yahaya , Aminu Muhammed, Abdulhakeem Haruna, Esther Oladele, Usman Liman   +4 more
doaj  

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source