Results 41 to 50 of about 105,445 (124)
Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System
Viruses, 2021 Viral infections remain a global public health concern and cause a severe societal and economic burden. At the organismal level, the innate immune system is essential for the detection of viruses and constitutes the first line of defense.
Hina Singh, Jeffrey Koury, Marcus Kaul
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Analysis of Hepatitis C Viral Dynamics Using Latin Hypercube Sampling [PDF]
, 2011 We consider a mathematical model comprising of four coupled ordinary differential equations (ODEs) for studying the hepatitis C (HCV) viral dynamics. The model embodies the efficacies of a combination therapy of interferon and ribavirin. A condition for the stability of the uninfected and the infected steady states is presented.
arxiv +1 more source
Poly I:C Pre-Treatment Induced the Anti-Viral Interferon Response in Airway Epithelial Cells
Viruses, 2023 Type I and III interferons are among the most important antiviral mediators. Increased susceptibility to infections has been described as being associated with impaired interferon response in asthmatic patients. In this work, we focused on the modulation
Hannah Mitländer +5 more
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GIFT: Guided and Interpretable Factorization for Tensors - An Application to Large-Scale Multi-platform Cancer Analysis [PDF]
, 2018 Given multi-platform genome data with prior knowledge of functional gene sets, how can we extract interpretable latent relationships between patients and genes? More specifically, how can we devise a tensor factorization method which produces an interpretable gene factor matrix based on gene set information while maintaining the decomposition quality ...
arxiv +1 more source
Interferons—Implications in the Immune Response to Respiratory Viruses
Microorganisms, 2023 Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that ...
Harrison C. Bergeron +2 more
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Journal of Indian Academy of Oral Medicine and Radiology, 2005 Interferons are a family of proteins and glycoproteins that have a variety of biologic actions. Interferons were first discovered in 1957 and several clinical trials have been conducted since then to unravel the action and clinical applications of ...
Karthikeya Patil +2 more
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Interferons in the treatment of myeloproliferative neoplasms
Therapeutic Advances in HematologyInterferons are cytokines with immunomodulatory properties and disease-modifying effects that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years.
Pankit Vachhani +11 more
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Immunity, Inflammation and Disease, 2020 Introduction CD64 expression increases on neutrophils during bacterial infections. Recently an increase in CD169 expression has been discovered on monocytes during viral infections.
Pénélope Bourgoin +4 more
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Инфекция и иммунитет, 2020 A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs.
M. P. Kostinov +7 more
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Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy
Cells, 2023 Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a ...
Kornél Z. Varga +8 more
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