Results 81 to 90 of about 418,590 (365)
Animals, 2019 Heat stress significantly impacts the immunity and cytokine expression of chickens. However, the effects of embryonic thermal manipulation (TM) on cytokine expression in broiler chickens (broilers) is unclear.
Khaled M. M. Saleh +1 more
doaj +1 more source
Pathogens, 2023 To enhance the efficacy of the current Newcastle disease vaccine, we have selected potential adjuvants that target well-characterized pattern recognition receptors: the toll-like receptors (TLRs). Imiquimod is a small-molecule activator of TLR7, which is
Chang-Won Lee +5 more
doaj +1 more source
Type III Interferons in Viral Infection and Antiviral Immunity
Cellular Physiology and Biochemistry, 2018 Interferons (IFNs) can serve as the first line of immune defense against viral infection. The identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral immune response to viruses contains more components than the type
Jian-hua Zhou +5 more
semanticscholar +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Hepatitis C Virus Infection: Host–Virus Interaction and Mechanisms of Viral Persistence
Cells, 2019 Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune factors along with the actions of HCV proteins that promote viral ...
DeGaulle I. Chigbu +4 more
doaj +1 more source
The Roles of Amphibian (Xenopus laevis) Macrophages during Chronic Frog Virus 3 Infections
Viruses, 2021 Infections by Frog Virus 3 (FV3) and other ranavirus genus members are significantly contributing to global amphibian decline. The Xenopus laevis frog is an ideal research platform upon which to study the roles of distinct frog leukocyte populations ...
Muhammad Riadul Haque Hossainey +4 more
doaj +1 more source
Effective Sample Size: Quick Estimation of the Effect of Related Samples in Genetic Case-Control Association Analyses [PDF]
Computational Biology and Chemistry, 35(1):40-49 (2011), 2006 Affected relatives are essential for pedigree linkage analysis, however, they cause a violation of the independent sample assumption in case-control association studies. To avoid the correlation between samples, a common practice is to take only one affected sample per pedigree in association analysis.
arxiv +1 more source
Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
Cellular Physiology and Biochemistry, 2018 The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional ...
Shi-Fang Li +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Modeling the dynamics of Hepatitis C Virus with combined antiviral drug therapy: Interferon and Ribavirin [PDF]
arXiv, 2011 A mathematical modeling of Hepatitis C Virus (HCV) dynamics has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions.
arxiv