Results 1 to 10 of about 24,455,487 (259)
Interleukin-1 as Innate Mediator of T Cell Immunity
Frontiers in Immunology, 2021 The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC molecules, which allows for a specific T cell response;
Bram Van Den Eeckhout +6 more
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Interleukin-1 and interleukin-1 antagonism [PDF]
Blood, 1991 The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a variety of genes and the synthesis of several proteins that, in turn, induce acute and chronic inflammatory changes.
C. Dinarello
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Chinese Journal of Lung Cancer, 2010 Interleukin-1 and Cancer Xiang WU, Ke XU Core Facility Center, Tianjin Medical University General Hospital; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China Corresponding author: Ke XU, E-mail: ke_xu@hotmail.com This study was ...
Xiang WU, Ke XU
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The role of interleukin-1 in general pathology
Inflammation and Regeneration, 2019 Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease.
Junya Masumoto +2 more
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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Nature Reviews Drug Discovery, 2012 Charles A Dinarello +2 more
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Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Nature, 2014 Katrin D Mayer-barber +2 more
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Open Biology, 2022 The cytokine interleukin 1 (IL-1) is an evolutionary innovation of vertebrates. Fish and amphibian have one IL1 gene, while mammals have two copies of IL1, IL1A and IL1B, with distinct expression patterns and differences in their proteolytic activation ...
Eva Hasel de Carvalho +4 more
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Applied Sciences, 2022 Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis ...
José Maria Cardoso +5 more
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Emerging Therapies for Recurrent Pericarditis: Interleukin‐1 inhibitors
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Recurrent pericarditis (RP) is a complex inflammatory disorder associated with adverse outcomes and poor quality of life. After the first episode of acute pericarditis, a non‐negligible group of patients will fail to achieve complete remission despite ...
Saberio Lo Presti +5 more
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Disease Activity Is More Associated with IL-1 Than with IL-6 in Patients with Rheumatoid Arthritis
Life, 2022 Interleukin-1 receptor antagonist (IL-1ra) concentration reflects and is proportional to IL-1 production. Both IL-1 and IL-6 are involved in the pathogenesis of rheumatoid arthritis (RA).
Cristina Almeida-Santiago +6 more
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