Results 41 to 50 of about 814,199 (330)

Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD), which are mostly seen in ...
Lindsey Barrett, Jungang Chen, Lu Dai, Karlie Plaisance-Bonstaff, Luis Del Valle, Zhiqiang Qin   +5 more
doaj   +1 more source

Interleukin 1 , interleukin 1  and interleukin 1 receptor gene polymorphisms in psoriatic arthritis [PDF]

Rheumatology, 2004
Objectives. To investigate polymorphisms of interleukin (IL) 1, IL-1 and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement. Methods. One hundred and forty well-characterized patients with PsA were studied.
openaire   +1 more source

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Osteoarthrosis or osteoarthritis? A current view of the disease and its treatment

Современная ревматология, 2013
The paper gives an update on the pathogenesis of osteoarthrosis, the role of anti-inflammatory cytokines in the destruction of cartilage and subchondral bone, and the possibility of targeted diacerein therapy.
Rimma Mikhailovna Balabanova
doaj   +1 more source

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. [PDF]

, 2015
BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation.
Interleukin 1 Genetics Consortium
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]

, 2006
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS, Aksentijevich, I, Beitz, LO, Brewer, C, Butman, JA, Canna, SW, Cole, JL, Dailey, NJ, Fuhlbrigge, RC, Gardner, G, Gelabert, A, Goldbach-Mansky, R, Hannan, WP, Haverkamp, MH, Hawkins, PN, Hill, S, Hoffmann, SC, Holland, SM, Horn, W, Jarvis, JN, Jones, J, Karp, BI, Kastner, DL, Kim, HJ, Moore, TL, O'Neil, K, Paul, SM, Penzak, SR, Pham, TH, Pucino, F, Rubin, BI, Shaham, B, Snyder, C, Stein, L, Turner, ML, Vehe, RK, Warren, RW, Wesley, RA, Wiggs, E, Zalewski, C   +39 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Serum amyloid A primes microglia for ATP-dependent interleukin-1\u3b2 release [PDF]

, 2018
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA).
A Basu, A Franceschini, AA Culbert, AJ Sharp, AL Giuliani, AM Van Dam, B Sperlágh, C Gabay, C Marinelli, C Solà, C Volonté, CA Dinarello, CM Uhlar, D Ferrari, D Kim, DL Thiele, E Gruys, E Nishida, E Venereau, G Guillemin, G Ristori, H Yokote, I Hardardóttir, I Kushner, I Rajkovic, J Saura, JA Sloane, JS Liang, JT Guo, K Chang, K Niemi, K Selmaj, L Facci, L Facci, L Peferoen, L Probert, L Sun, L Yao, Laura Facci, LK Parvathenani, M Barbierato, M Barbierato, M Casula, M Connolly, M De Buck, M Idzko, M Li, M Sanz, Massimo Barbierato, ME Hamby, MK McCoy, Morena Zusso, MS Kindy, MT Heneka, N Chauvet, N Cheng, P Honore, Pietro Giusti, R Ebert, RA Dal Canto, RJ Rodrigues, S Kim, S Sandri, S Tanaka, SD Skaper, SD Skaper, SD Skaper, SJ Crocker, SJ Hewett, SL Passey, SM Allan, Stephen D. Skaper, SY Seong, T Kawamoto, T Miida, T Tamamoto, TF Chung, TH Holm, XQ Li, Y Kumon, Y Wang, Y Yu, YR Ji   +82 more
core   +2 more sources