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Impacts of Interleukin-10 Promoter Genotypes on Prostate Cancer. [PDF]
Life (Basel)Chin YT +10 more
europepmc +1 more source
Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain. [PDF]
Brain Behav ImmunInyang KE +18 more
europepmc +1 more source
Tensile force impairs lip muscle regeneration under the regulation of interleukin-10. [PDF]
J Cachexia Sarcopenia MuscleCheng X +5 more
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Current Opinion in Immunology, 1992
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure
R, de Waal Malefyt +4 more
+7 more sources
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure
R, de Waal Malefyt +4 more
+7 more sources
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006
Interleukin (IL)-10, initially described as cytokine synthesis inhibitory factor, is a pleotropic cytokine produced by many cell populations. Its main biological functions appear to be quite diverse: on the one hand it is involved in the limitation and termination of inflammatory responses and the regulation of differentiation and proliferation of ...
K. Asadullah +5 more
+5 more sources
Interleukin (IL)-10, initially described as cytokine synthesis inhibitory factor, is a pleotropic cytokine produced by many cell populations. Its main biological functions appear to be quite diverse: on the one hand it is involved in the limitation and termination of inflammatory responses and the regulation of differentiation and proliferation of ...
K. Asadullah +5 more
+5 more sources
Annual Review of Immunology, 1993
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector ...
K W, Moore +4 more
openaire +3 more sources
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector ...
K W, Moore +4 more
openaire +3 more sources
BioDrugs, 1997
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel +2 more
openaire +3 more sources
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel +2 more
openaire +3 more sources
Interleukin-10 and the Interleukin-10 Receptor
Annual Review of Immunology, 2001Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses.
K W, Moore +3 more
openaire +2 more sources
Progress in Growth Factor Research, 1992
Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
D, Rennick, D, Berg, G, Holland
openaire +2 more sources
Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
D, Rennick, D, Berg, G, Holland
openaire +2 more sources
Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease
Current Allergy and Asthma Reports, 2012Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (
Shah, Neil +3 more
openaire +3 more sources