Results 271 to 280 of about 633,289 (295)

Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus

Clinical Rheumatology, 2013
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by excessive production of a variety of autoantibodies, accumulation of immune complexes, and multiple organ systems involvement. Interleukin-10 (IL-10) has an important role in the growth, survival, differentiation, and function of B cells.
Dong-Qing Ye, Hui Peng, Hai-Feng Pan, Wei Wang, Mo Zhou, Rui Li   +5 more
openaire   +3 more sources

The interleukin-10 family of cytokines

Trends in Immunology, 2002
A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence paralogs, including IL-19, IL-20, IL-22 [IL-10-related T-cell-derived inducible factor (IL-TIF)], IL-24 [melanoma differentiation-associated antigen 7 (MDA-7)] and IL-26 (AK155).
Sabine Wittmann, Helmut Fickenscher, Heide Küpers, Simon Hör, Andrea Knappe, Heinrich Sticht   +5 more
openaire   +3 more sources

Biological properties of interleukin 10

Journal of Clinical Immunology, 1992
Interleukin 10 (IL-10) was discovered in 1989 by Mosmann and colleagues as an activity produced by murine type 2 helper T cells which suppressed cytokine production by type 1 helper T cells (1). This activity, initially designated cytokine synthesis inhibitor factor (CSIF), was isolated by expression cloning by Moore and colleagues (2), who ...
M Howard, de Waal Malefyt R, Ishida H, de Vries J, Anne O'Garra   +4 more
openaire   +6 more sources

A Gly15Arg Mutation in the Interleukin-10 Gene Reduces Secretion of Interleukin-10 in Crohn Disease

Scandinavian Journal of Gastroenterology, 2003
Genetic susceptibility, probably involving cytokines and their receptors, plays an important role in inflammatory bowel disease (IBD). In this study we examine the potential role of the interleukin-10 (IL-10) gene as a susceptibility gene in IBD.We studied 17 sib-pairs with either Crohn disease (CD) or ulcerative colitis.
van der Linde, K., Boor, P.P.C., Sandkuijl, L.A., Meijssen, M.A.C., Savelkoul, H.F.J., Wilson, J.H.P., Rooij, F.W.M.   +6 more
openaire   +4 more sources

Interleukin-10

BioDrugs, 1997
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel, Velu, Thierry, Pretolani, M.   +2 more
openaire   +3 more sources

Regulation of Interleukin-10 Expression

2016
Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota.
Sascha Rutz, Wenjun Ouyang
openaire   +3 more sources

Expression and regulation of interleukin‐10 and interleukin‐10 receptor in rat astroglial and microglial cells

European Journal of Neuroscience, 2002
AbstractActivated glial cells crucially contribute to brain inflammatory responses. Interleukin‐10 (IL‐10) is an important modulator of glial cell responses in the brain. In the present study we describe the expression of IL‐10 and the IL‐10 receptor (IL‐10R1) in primary cocultures of rat microglial and astroglial cells.
Ledeboer, Annemarie, Brevé, John J P, Wierinckx, Anne, van der Jagt, Saskia, Bristow, Adrian F, Leysen, Josée E, Tilders, Fred J H, Van Dam, Anne-Marie   +7 more
openaire   +4 more sources

Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes.

Clinical and experimental rheumatology, 2001
To evaluate the expression of interleukin-10 (IL-10) and interleukin-10 receptor (IL-10R) on chondrocytes from healthy, osteoarthritic, and foetal cartilage from human subjects.Articular cartilage was obtained from 12 patients with osteoarthritis (OA) undergoing surgical knee replacement.
Iannone, F, De Bari, C, Dell'Accio, F, Covelli, M, Cantatore, F P, Patella, V, Lo Bianco, G, Lapadula, G   +7 more
openaire   +2 more sources

Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients*

Critical Care Medicine, 2003
To determine the functionality of identified polymorphisms in the promoter and upstream regions of the interleukin-10 gene in terms of release of interleukin-10 from lipopolysaccharide-stimulated whole blood from healthy volunteers and to evaluate the relationship of interleukin-10 polymorphisms to interleukin-10 release, development of sepsis, and ...
A. Abdel-Fattah, Nigel R. Webster, Helen F. Galley, Peter Lowe   +3 more
openaire   +3 more sources

Properties and Functions of Interleukin-10

1994
Publisher Summary This chapter focuses on properties and functions of interleukin-10. IL10 inhibits several macrophage functions, including some microbicidal properties and presentation of antigen to TH 1 cells. In contrast, IL10 has generally enhancing or stimulatory functions on B cells and mast cells.
openaire   +3 more sources