Results 51 to 60 of about 10,723,036 (376)

IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception

Brain Sciences, 2023
Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the ...
Thiago Caetano Andrade Belo, Gabriela Xavier Santos, Bruno Eduardo Gabriel da Silva, Bruno Lopes Gonçalves Rocha, Dennis William Abdala, Larissa Alves Moreira Freire, Fernanda Santos Rocha, Giovane Galdino   +7 more
doaj   +1 more source

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

Journal of Experimental Medicine, 1991
Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cell clones when monocytes were used as antigen-presenting cells.
R. D. Malefyt, J. Haanen, H. Spits, M. Roncarolo, A. Velde, C. Figdor, K. E. Johnson, R. Kastelein, H. Yssel, J. D. Vries   +9 more
semanticscholar   +1 more source

Prevention of arthritis by interleukin 10-producing B cells [PDF]

, 2003
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Gray, D., Londei, M., Mauri, C., Mushtaq, N.   +3 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China

Journal of Infection in Developing Countries
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern.
Xiaoyi Liu, Fan Zhang, Jinping Qiao, Wentao He   +3 more
doaj   +1 more source

Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Brazilian Oral Research, 2018
: Susceptible genotypes to periodontal disease are associated with disease onset and progression. The aim of this study was to examine the effect of gene polymorphisms on the risk of further disease progression and the need for further treatment among ...
Georgios Chatzopoulos, Aikaterini-Ellisavet Doufexi, Larry Wolff, Anastasia Kouvatsi   +3 more
doaj   +1 more source

CD4+ T cell hyporesponsiveness after repeated exposure to Schistosoma mansoni larvae is dependent upon interleukin-10 [PDF]

, 2015
The effect that multiple percutaneous exposures to Schistosoma larvae has on the development of early CD4+ lymphocyte reactivity is unclear, yet it is important in the context of humans living in areas where schistosomiasis is endemic.
Cook, Peter C., Mountford, Adrian P., Prendergast, Catriona T., Sanin, David E.   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

THE ASSOCIATION OF PROCALCITONIN, LACTATE, WBC COUNT, AND INTERLEUKIN-10 MAY BE HELPFUL IN THE EARLY DIAGNOSIS OF SEPSIS IN BRAZILIAN PATIENTS

Arquivos de Ciências da Saúde da UNIPAR
Introduction: Sepsis is a set of clinical symptoms resulting from inflammation and infection. Several biomarkers are used for early diagnosis and improved management of sepsis.
Cristiane Alves da Silva Menezes, Victor Hugo Ferreira Gomes, Fernanda Rocha de Freitas, Simone Martins Gonçalves, Pâmela Santos Azevedo, Edna Afonso Reis, Ieda de Fátima Oliveira Silva, Ana Paula Lucas Mota   +7 more
doaj   +1 more source

Serum interleukin 1 and interleukin 10 levels in Iraqi leukemic patients with hepatitis G virus infection.

مجلة كلية الطب, 2013
Background: Objectives : This prospective   study aimed to  estimate interleukins 1 and 10  levels in acute  hepatitis (G) in Iraqi patients with leukemiaHepatitis G virus and GB virus C (GBV-C)  RNA viruses that were independently identified in 1995,
Muhammad M. Alani
doaj   +1 more source