Results 1 to 10 of about 6,238,612 (332)

Localized Interleukin-12 for Cancer Immunotherapy

Frontiers in Immunology, 2020
Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Khue G. Nguyen, Maura R. Vrabel, Siena M. Mantooth, Jared J. Hopkins, Ethan S. Wagner, Taylor A. Gabaldon, David A. Zaharoff   +6 more
doaj   +2 more sources

Plasma interleukin-12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia [PDF]

Blood Research
Background Fatigue significantly affects health-related quality of life (HRQoL) in patients with immune thrombocytopenia (ITP). However, the interplay between fatigue and cytokines in ITP remains poorly understood.
Sarthak Wadhera, Arihant Jain, Aarushi Sahni, Rudra Narayan Swain, Charanpreet Singh, Aditya Jandial, Ritu Aggarwal, Rekha Hans, Gaurav Prakash, Alka Khadwal, Sandeep Grover, Reena Das, Pankaj Malhotra   +12 more
doaj   +2 more sources

Interleukin 12 Measurement [PDF]

Definitions, 2020
The determination of the amount of interleukin 12 present in a sample.
openaire   +2 more sources

Interleukin-12 family cytokines and sarcoidosis

Frontiers in Pharmacology, 2014
Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski, Sabine eRingkowski, Cristan eHerbert, Paul S. Thomas   +3 more
doaj   +2 more sources

Atomic Pt-Layer-Coated Au Peroxidase Nanozymes with Enhanced Activity for Ultrasensitive Colorimetric Immunoassay of Interleukin-12 [PDF]

Biosensors
Interleukin-12 (IL-12), a crucial biomarker for immune and inflammatory responses, plays a pivotal role in diagnosing and managing diverse pathological conditions.
Han Zhang, Xiang Peng, Hao Song, Yongfeng Tan, Jianglian Xu, Qunfang Li, Zhuangqiang Gao   +6 more
doaj   +2 more sources

Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model [PDF]

Molecular Therapy: Oncology
Interleukin-12 (IL-12) is a promising pro-inflammatory cytokine for cancer immunotherapy, but its toxicity and short half-life in serum limit its clinical application.
Chuyuan Chen, Yongji Jiang, Chuan Feng, Qingyun Zhou, Xingrong Luo, Lili Cai, Lei Zhao   +6 more
doaj   +2 more sources

Interleukin-12 [PDF]

Definitions, 2020
openaire   +2 more sources

Recombinant Interleukin-12 [PDF]

Definitions, 2020
openaire   +2 more sources

Prospects for the use of monoclonal antibodies to interleukin 23 Gusеlkumab in psoriatic arthritis: New data

Научно-практическая ревматология, 2022
Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov, T. V. Korotaeva, S. Rodolfi, C. F. Selmi   +3 more
doaj   +1 more source

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

BMC Medical Genetics, 2020
Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei, Sina Abdollahzade, Maryam Sadr, Mohammad Hossein Mirbolouk, Ehsan Fattahi, Alireza Khoshnevisan, Nima Rezaei   +6 more
doaj   +1 more source