Results 311 to 320 of about 668,836 (354)

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

Annual Review of Immunology, 1998
▪ Abstract  Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its activities are mediated through a high-affinity receptor composed of two subunits, designated β1 and β2.
M K, Gately, L M, Renzetti, J, Magram, A S, Stern, L, Adorini, U, Gubler, D H, Presky   +6 more
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Interleukin 12 and autoimmune diabetes

Nature Genetics, 2001
Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B).
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Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

European Journal of Immunology, 1999
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-bonded subunits, p35 and p40, which has important regulatory effects on T cells and natural killer (NK) cells. In contrast to heterodimeric IL-12, a homodimer of the p40 subunit, designated (p40)2, has been shown to be a potent IL-12 antagonist.
X, Wang, V L, Wilkinson, F J, Podlaski, C, Wu, A S, Stern, D H, Presky, J, Magram   +6 more
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Immunoregulation of murine leishmaniasis by interleukin-12

Research in Immunology, 1995
Distinct phenotypic outcomes following infection of mice with Leishmania major are closely linked to the emergence of functionally dissimilar Th1 or Th2 CD4+ T-cell responses early in the course of disease. This model of T-cell-dependent microbial pathology has proven useful for the study of cytokine regulatory and effector functions in vivo.
F P, Heinzel, F, Ahmed, A M, Hujer, R M, Rerko   +3 more
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Antitumor and antimetastatic effects of interleukin 12

Cancer Chemotherapy and Pharmacology, 1996
Interleukin 12 (IL-12) has a pivotal role in controlling cell-mediated immunity through a number of important biological activities, such as secretion of interferon-gamma (IFN-gamma). In this review, we report our recent results regarding the antitumor and antimetastatic effects of IL-12.
H, Fujiwara, T, Hamaoka
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Interleukin-12 and malaria

Research in Immunology, 1995
J M, Crutcher, M M, Stevenson, M, Sedegah, S L, Hoffman   +3 more
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Production of interleukin-12

Research in Immunology, 1995
X, Ma, A, D'Andrea, M, Kubin, M, Aste-Amezaga, A, Sartori, J, Monteiro, L, Showe, M, Wysocka, G, Trinchieri   +8 more
openaire   +2 more sources

Interleukin-12

Inpharma Weekly, 1998
Richard Chizzonite, Ueli Gubler, Jeanne Magram, Alvin S. Stern   +3 more
openaire   +2 more sources

The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.

Cancer research, 1997
Use of the cytokine interleukin 12 (IL-12) has been shown to enhance the rejection of a variety of murine tumors, but preclinical and clinical studies have revealed that recombinant IL-12 (rlL-12) can produce severe toxicity. In an effort to improve the tolerance and therapeutic effectiveness of this cytokine, we investigated the influence of giving a ...
C M, Coughlin, M, Wysocka, G, Trinchieri, W M, Lee   +3 more
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Producer cells of interleukin 12

Parasitology Today, 1993
G, Trinchieri, M, Rengaraju, A, D'Andrea, N M, Valiante, M, Kubin, M, Aste, J, Chehimi   +6 more
openaire   +2 more sources