Results 31 to 40 of about 6,238,612 (332)

Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus

open access: yesMolecular Therapy: Oncolytics, 2023
Oncolytic viruses are of significant clinical interest due to their ability to directly infect and kill tumors and enhance the anti-tumor immune response.
Soon-Oh Hong   +15 more
doaj   +1 more source

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis.

open access: yesPLoS ONE, 2017
A crucial role of cell metabolism in immune cell differentiation and function has been recently established. Growing evidence indicates that metabolic processes impact both, innate and adaptive immunity.
Johannes J Kovarik   +16 more
doaj   +1 more source

Significance of the determination of proinflammatory cytokines in the serum of polytraumatized patients with sepsis [PDF]

open access: yesVojnosanitetski Pregled, 2004
Severe sepsis and trauma complicated with multiple organ dysfunction syndrome (MODS) are among the leading causes of death in intensive therapy units with mortality rate exceeding 50%.
Šurbatović Maja   +4 more
doaj   +1 more source

Follicular fluid cytokine concentration impact on oocyte maturity, embryo quality and pregnancy outcomes during ovarian stimulation cycles in infertile women [PDF]

open access: yesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2022
Introduction: Since cytokines in follicular fluid play an important role in ovulation and oocyte maturation, they also have an essential role in reproductive processes such as fertilization, early embryonic development, and implantation potential.
Faezaneh Fesahat   +6 more
doaj   +1 more source

Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

open access: yesPharmaceuticals, 2023
The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses.
Nikolas T. Martin   +17 more
doaj   +1 more source

Early Interferon-γ Production in Human Lymphocyte Subsets in Response to Nontyphoidal Salmonella Demonstrates Inherent Capacity in Innate Cells [PDF]

open access: yes, 2010
Background Nontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Anna E. Seeley   +5 more
core   +3 more sources

Iron as Preoperative Antituberculosis Supplement Increases Interleukin-12 Level in Spinal Tuberculosis and Iron Deficiency Patients

open access: yesJurnal Anestesi Perioperatif, 2020
Iron deficiency remains the most prevalent micronutrient deficiency worldwide. Iron deficiency in TB patients, causes a poor outcome, reccurency, and treatment failure. Iron supplements on TB patients with iron deficiency will activate macrophage-derived
Anggi Fauziani   +2 more
doaj   +1 more source

Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions [PDF]

open access: yes, 2003
Background - Antigen-presenting cells (APCs) such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation in the course of adaptive immunity.
Aicher, A   +5 more
core   +1 more source

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25

open access: yesOncoImmunology, 2018
Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan   +9 more
doaj   +1 more source

Interleukin-12 in infectious diseases [PDF]

open access: yesClinical Microbiology Reviews, 1997
Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity ...
ROMANI, Luigina   +2 more
openaire   +3 more sources

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