Results 31 to 40 of about 657,016 (309)
Interleukin-12 in infectious diseases [PDF]
Clinical Microbiology Reviews, 1997 Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity ...
ROMANI, Luigina +2 more
openaire +3 more sources
OncoImmunology, 2018 Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells produce stimulatory cytokines (e.g., IFN-γ) in response to potent stimulation via immobilized IgG (to engage
Megan C. Duggan +9 more
doaj +1 more source
Interleukin-12 family cytokines and sarcoidosis
Frontiers in Pharmacology, 2014 Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified.
Sabine eRingkowski +3 more
doaj +1 more source
Interleukin-12 in Human Milk [PDF]
Pediatric Research, 1999 The presence of interleukin-12 (IL-12) in 39 samples of human milk was investigated using the enzyme-linked immunosorbent assay. IL-12 (>40 pg/mL) was detected in 24 of the 39 samples collected (1408 +/- 2256 pg/mL, mean +/- SD, n = 24). A range of concentrations of IL-12 was observed in colostrum, transitional, and mature milk, with an apparent ...
D L, Bryan, J S, Hawkes, R A, Gibson
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2022 Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy.
Noelia Silva-Pilipich +5 more
doaj +1 more source
Interleukin-12 and photocarcinogenesis [PDF]
Toxicology and Applied Pharmacology, 2007 UV radiation induces immunosuppression and inflammatory responses, as well as oxidative stress and DNA damage, in skin cells and these various effects have been implicated in melanoma and nonmelanoma skin cancers, i.e., photocarcinogenesis. The cytokine interleukin (IL)-12 has been shown to possess potent antitumor activity in a wide variety of murine ...
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda +15 more
wiley +1 more source
Accelerated wound healing phenotype in Interleukin 12/23 deficient mice
Journal of Inflammation, 2011 Background The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present
Matias Marie AT +4 more
doaj +1 more source
Natural killer cells as an initial defense against pathogens. [PDF]
, 2006 Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
core
Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12 [PDF]
, 2001 Despite the efficacy of IL-12 in cancer experimental models, clinical trials with systemic recombinant IL-12 showed unacceptable toxicity related to endogenous IFNgamma production.
Mazzolini, G. (Guillermo) +8 more
core +1 more source