Results 21 to 30 of about 3,870,583 (322)
Cochrane Database of Systematic Reviews, 2021 BACKGROUND Targeting the immunoglobulin E pathway and the interleukin-5 pathway with specific monoclonal antibodies directed against the cytokines or their receptors is effective in patients with severe asthma.
Andrew Gallagher +8 more
semanticscholar +1 more source
Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function
Allergy. European Journal of Allergy and Clinical Immunology, 2021 Eosinophilic esophagitis (EoE) is a food allergen driven disease that is accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction allowing transepithelial food allergen permeation.
M. Kleuskens +7 more
semanticscholar +1 more source
Selective IL-13 inhibitors for the treatment of atopic dermatitis
Drugs in Context, 2021 Background: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. AD pathogenesis is multifactorial, involving environmental and genetic factors.
Francisca Gonçalves +2 more
doaj +1 more source
Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis
Frontiers in Immunology, 2023 BackgroundFibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall.
Kristina Koop +19 more
doaj +1 more source
Association of interleukin-13 gene variants with susceptibility to brucellosis [PDF]
Trends in Pharmaceutical Sciences, 2016 Brucella is an intracellular Gram-negative bacterium. Previous reports showed that gene polymorphisms of cytokines can affect resistance or susceptibility to Brucella infection.
Sayed-Jalal-Aladin Ashraf-Mansuri +5 more
doaj +2 more sources
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
Science, 2020 IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al.
Nelson H. Knudsen +20 more
semanticscholar +1 more source
Mutants of Interleukin 13 with Altered Reactivity toward Interleukin 13 Receptors [PDF]
Journal of Biological Chemistry, 1999 Interleukin 13 (IL13) belongs to a family of cytokines whose members exhibit structural homology, despite amino acid sequence dissimilarity. For example, while of limited sequence homology, IL13 and IL4 share a signaling receptor, IL13/4 receptor, on a variety of human normal cells. However, a subclass of IL4-independent IL13 receptors is overexpressed
J P, Thompson, W, Debinski
openaire +2 more sources
Viruses, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
John Foerster, Aleksandra Molęda
doaj +1 more source
Characterization of the Interaction between Interleukin-13 and Interleukin-13 Receptors [PDF]
Journal of Biological Chemistry, 2005 Interleukin-13 (IL-13) possesses two types of receptor: the heterodimer, composed of the IL-13Ralpha1 chain (IL-13Ralpha1) and the IL-4Ralpha chain (IL-4Ralpha), transducing the IL-13 signals; and the IL-13Ralpha2 chain (IL-13Ralpha2), acting as a nonsignaling "decoy" receptor.
Kazuhiko, Arima +8 more
openaire +2 more sources
Interleukin‐13: Targeting an underestimated cytokine in atopic dermatitis
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been considered a paradigmatic type 2 immunity (T2)‐driven disease.
T. Bieber
semanticscholar +1 more source