Results 81 to 90 of about 68,936,161 (293)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome

Folia Histochemica et Cytobiologica, 2010
Cytokines participate in many physiological processes including the regulation of immune and inflammatoryresponses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased .
Joanna Smigielska- Kuzia, Leszek Boækowski, Wojciech Sobaniec, Krzysztof Sendrowski, Beata Żelazowska- Rutkowska, Magdalena Cholewa   +5 more
doaj  

Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts

Allergology International, 2001
Background: Interleukin (IL)-4 and IL-13, which play a role in the production of allergic inflammation, can activate fibroblasts to elicit a variety of cellular functions.
Tatsuya Machino, Shu Hashimoto, Yasuhiro Gon, Kosei Kujime, Shuichiro Maruoka, Takashi Horie   +5 more
doaj   +1 more source

Expression of Markers of Activity in Cultured Human Osteoblasts : Effects of Interleukin-4 and Interleukin-13

, 2010
Cytokines regulate proliferation, differentiation and activation of osteoblasts. Interleukin-4 (IL-4) and interleukin-13 (IL-13) takes part in this regulation by inhibiting proliferation and by enhancement of interleukin-6 (IL-6) formation in cultured ...
Nilsson, Olle,, Ljunggren, Östen,, Silfverswärd, Carl-Johan,, Penno, Hendrik,, Frost, Anders,   +4 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway

, 2002
Granulomatous Diseases Review Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production ...
Kumararatne, D.S., Baretto, Richard, De Heer, E., J.F. EMILE, Ottenhoff, THM, De Heer, E, Edgar, JD, Binch, J., Ottenhoff, T.H., Casanova, J.L., Lammas, David, Lammas, D.A., Edgar, J, Kumararatne, DS, Panchalingam, S, Novelli, V., E. DE HEER, Drysdale, P, Binch, J, Ottenhoff, TH, Panchalingam, S., Emile, JF, Drysdale, Pamela, C. MACLENNAN, T. H. M. OTTENHOFF, Ben-smith, Anne, Novelli, V, P. DRYSDALE, MacLennan, Calman, R. BARETTO, Casanova, JL, J. BINCH, Ben-Smith, A., Casanova, J-L, Ben-Smith, A, Drysdale, P., Emile, J.F., D. S. KUMARARATNE, Baretto, R, Baretto, R., S. PANCHALINGAM, J.-L. CASANOVA, MacLennan, C, J. D. EDGAR, A. BEN-SMITH, Kumararatne, Dinakantha, D. A. LAMMAS, MacLennan, C., Lammas, David A, V. NOVELLI   +49 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Effect of 1,25-dihydroxy vitamin D3 on expression of pro-inflammatory cytokines in type Ⅱ innate lymphoid cells in

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of 1,25-dihydroxy vitamin D3 [1,25-(OH)2-D3] on the expression of pro-inflammatory cytokines in type Ⅱ innate lymphoid cells (ILC2s) in asthmatic mice.
LI Chengcheng, WU Yi
doaj   +1 more source