Results 1 to 10 of about 563,024 (285)

Giant Cell Arteritis Refractory to Interleukin‐6 and Interleukin‐17 Inhibition Treated With Upadacitinib [PDF]

ACR Open Rheumatology
Giant cell arteritis (GCA) is a granulomatous vasculitis that can involve both cranial and extracranial vessels. Although interleukin‐6 (IL‐6) receptor blockade is an established therapy, treatment options for medically refractory disease remain limited.
Luke S. Vest, Anam Ahmad, Sanhitha Valasareddy, Nancy Phillips, Adam Kilian   +4 more
doaj   +4 more sources

The parasitic helminth product ES‐62 suppresses pathogenesis in collagen‐induced arthritis by targeting the interleukin‐17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Miguel A. Pineda, Mairi McGrath, Pauline C. Smith, Lamyaa Al‐Riyami, Justyna Rzepecka, J. Alastair Gracie, William Harnett, Margaret M. Harnett   +7 more
openalex   +4 more sources

IL17A and IL17RA gene polymorphisms in Fanconi anemia [PDF]

Brazilian Oral Research, 2023
Fanconi anemia is a rare autosomal recessive disease. In this disease, cytokine pathways can induce the bone marrow failure that is observed in individuals with Fanconi anemia.
Rafael Zancan MOBILE, Monalisa Castilho MENDES, Cleber MACHADO-SOUZA, Priscila de Mattos QUEIROZ, Carmem Maria Sales BONFIM, Cassius Carvalho TORRES-PEREIRA, Juliana Lucena SCHUSSEL   +6 more
doaj   +1 more source

Endometrial senescence is mediated by interleukin 17 receptor B signaling [PDF]

Cell Communication and Signaling
Background We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While IL17RB has been linked to inflammation and malignancies in several organ systems, its function in the endometrium has ...
Keiko Kawamura, Yumiko Matsumura, Teruhiko Kawamura, Hiromitsu Araki, Norio Hamada, Kazutaka Kuramoto, Hiroshi Yagi, Ichiro Onoyama, Kazuo Asanoma, Kiyoko Kato   +9 more
doaj   +2 more sources

Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification

Applied Sciences, 2022
Background: Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of periodontium support tissue generated by different immuno-inflammatory mechanisms, including the RANK/RANKL/OPG and the IL-23/IL-17 axis.
Ruth Rodríguez-Montaño, Alondra del Carmen Ruiz-Gutiérrez, Vianeth María del Carmen Martínez-Rodríguez, Juan Ramón Gómez-Sandoval, Juan Manuel Guzmán-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velázquez   +7 more
doaj   +1 more source

Interleukin 17 in early invasive breast cancer

Frontiers in Oncology, 2023
IntroductionInterleukin 17 (IL-17) has a key role in inflammatory responses. Increased serum concentrations of IL-17 have been reported in patients with different types of cancer.
Marina Popović, Marina Popović, Natalija Dedić Plavetić, Natalija Dedić Plavetić, Damir Vrbanec, Zlatko Marušić, Zlatko Marušić, Davor Mijatović, Davor Mijatović, Ana Kulić   +9 more
doaj   +1 more source

Role of Interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression [PDF]

, 2010
Background: The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition, response will be often lost when treatment is stopped. These clinical aspects indicate that other
A Maitra, Anne Tournadre, B Bennett, B Gao, D Alessi, D Borderie, D Borderie, D Eizirik, D Lacey, D Toy, David Boyle, Derya Unutmaz, E Bettelli, E Lubberts, E Nadav, Erik Lubberts, F Arnett, G Firestein, G Page, Gaelle Gonzales, Gary S. Firestein, H Hsu, H Nakamura, J Anolik, J Dufour, J Lee, K Aupperle, L Harrington, M Kaneko, M Kikkert, M Koenders, M Leech, M Toh, M Toh, M Toh, M Toh, Marije I. Koenders, MI Koenders, Myew-Ling Toh, N Yagishita, P Miossec, Pierre Miossec, Q Chen, R Swandner, S Chang, S Cohen, S Hwang, S Hymowitz, S Oyadomari, S Yamasaki, S Zrioual, S Zrioual, T Amano, T Amano, T Gotoh, Wim B. van den Berg, Y Qian, Yuan Zhou, Z You   +58 more
core   +17 more sources

Interleukin-17 Cytokines and Receptors: Potential Amplifiers of Tendon Inflammation

Frontiers in Bioengineering and Biotechnology, 2021
Interleukin (IL)-17A, a pro-inflammatory cytokine that is linked to the pathology of several inflammatory diseases, has been shown to be upregulated in early human tendinopathy and to mediate inflammatory and tissue remodelling events.
Jolet Y. Mimpen, Sarah J. B. Snelling, Andrew J. Carr, Stephanie G. Dakin   +3 more
doaj   +1 more source

Relationship between interleukin 17 & 6 in patients with varicocele compare with a control group [PDF]

Journal of Medical and Life Science, 2019
The spermatogenesis process is very complex and involves many processes that lead to giving normal sperm, these sperms are very important for Fertility in the male.
Hayder AL-Msaid, Waleed H., Hydar Khalfa
doaj   +1 more source

Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

Revista da Sociedade Brasileira de Medicina Tropical, 2021
A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the ...
Patrícia Shu Kurizky, Jorgeth de Oliveira Carneiro da Motta, Natanael Victor Furtunato Bezerra, Marcia Carolline dos Santos Sousa, Danilo Corazza, Taiana Karla dos Santos Borges, Ciro Martins Gomes   +6 more
doaj   +1 more source