The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]
, 2012 Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami +47 more
core +1 more source
Interleukin-17 in Chronic Inflammatory Neurological Diseases
Frontiers in Immunology, 2020 A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases.
J. Milovanović +7 more
semanticscholar +1 more source
Airway neutrophils and interleukin-17 [PDF]
European Respiratory Journal, 2000 It is well known that exacerbations of obstructive airways disease such as asthma and chronic obstructive pulmonary disease are associated with an increased number of neutrophils in the airways. However, the mechanisms behind this phenomenon are poorly understood.
A, Lindén, H, Hoshino, M, Laan
openaire +2 more sources
Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
Frontiers in Immunology, 2020 The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer.
Yun Ge, Man Huang, Yong-ming Yao
semanticscholar +1 more source
The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis [PDF]
, 2014 S-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth infection.
Harnett, Margaret +2 more
core +1 more source
Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease [PDF]
Immunology, 2010 SummaryInterleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL‐17‐producing cells are generated.
Reiko M, Onishi, Sarah L, Gaffen
openaire +2 more sources
Serum interleukin-17 (IL-17) in chronic periodontitis patients
Padjadjaran Journal of Dentistry, 2017 Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease ...
Erry Mochamad Arief +4 more
doaj +1 more source
The Treatment with Interleukin 17 Inhibitors and Immune-Mediated Inflammatory Diseases
Current Issues in Molecular Biology, 2022 IL-17 inhibitors (IL-17i) are medicines used to treat dermatological and rheumatic diseases They belong to a class of medicines called biological disease-modifying anti-rheumatic drugs (bDMARDs).
Laura Țiburcă +6 more
doaj +1 more source
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]
, 2017 In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus +6 more
core +2 more sources
The role of interleukin-17 in asthma: a protective response?
ERJ Open Research, 2020 While there now exist effective treatments for type 2 high, eosinophilic asthma, there are no specific therapies for 40–50% of people with asthma with other phenotypes, which result from poorly understood underlying pathological mechanisms.
G. Hynes, T. Hinks
semanticscholar +1 more source