Targeting interleukin-17 receptors
Oncotarget, 2015 During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Chun-Kai Huang +2 more
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Interleukin 17-A inhibition in the treatment of psoriasis [PDF]
Expert Review of Clinical Immunology, 2015 Interleukin (IL) 17-A appears to be integral to the pathogenesis of chronic plaque psoriasis. Recent clinical trials have shown that blockade of this cytokine with the biologic therapies--secukinumab, ixekizumab and brodalumab--have led to unprecedented treatment efficacy for psoriasis.
Yiu, Zenas Zn, Griffiths, Christopher Em
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Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence [PDF]
, 2012 Original Research ArticleIntroduction. This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium,
Bannister, Jim R. +4 more
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Serum interleukin-17 (IL-17) in chronic periodontitis patients
Padjadjaran Journal of Dentistry, 2017 Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease ...
Erry Mochamad Arief +4 more
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Faecalibacterium prausnitziiinhibits interleukin-17 to ameliorate colorectal colitis in rats [PDF]
, 2014 © 2014 Zhang et al. Results: The culture supernatant of F. prausnitzii increased plasma anti-Th17 cytokines (IL-10 and IL-12) and suppressed IL-17 levels in both plasma and colonic mucosa, with ameliorated colonic colitis lesions.
Chen, H +7 more
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Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling [PDF]
, 2010 By binding to the interleukin 17 receptor (IL-17R), TRAF3 blocks formation of the IL-17R–Act1–TRAF6 complex and inhibits downstream ...
Gao, Hanchao +10 more
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Interleukin-17 in Various Ocular Surface Inflammatory Diseases [PDF]
, 2011 Recently, the association of Th-17 cells or IL-17 with ocular inflammatory diseases such as uveitis, scleritis and dry eye syndrome was discovered. We assessed whether interleukin (IL)-17 was present in the tears of various ocular surface inflammatory ...
Aggarwal +35 more
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Analysis of Interleukin-17 Levels in Patients with Thrombocytopenia [PDF]
, 2020 Thrombocytopenia or platelet deficiency is a condition, in which platelet level in the blood circulation is below normal, which is less than 150,000 cells/µl.
Arief, Mansyur +2 more
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production [PDF]
, 2010 Mycophenolic acid is a commonly used immunosuppressant after organ transplantation and in autoimmune diseases; however, myelosuppression is a major complication despite its largely favorable side-effect profile.
Ley, Klaus +2 more
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