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Interleukin-17 family and IL-17 receptors
Cytokine & Growth Factor Reviews, 2003Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified ...
T A, Moseley +3 more
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Critical role of interleukin‐17/interleukin‐17 receptor axis in mediating Con A‐induced hepatitis
Immunology & Cell Biology, 2011Concanavalin A (Con A)‐induced hepatitis is thought to be a T‐cell‐mediated disease with active destruction of liver cells. Interleukin (IL)‐17 is a cytokine produced principally by CD4+ T cells. However, whether IL‐17/IL‐17 receptor (IL‐17/IL‐17R)‐mediated responses are involved in T‐cell‐mediated Con A‐induced liver injury remains unclear.
Shu, Yan +4 more
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European Journal of Cancer, 2014
Material and Methods: To evaluate the extent of ITH in colorectal cancer (CRC) with microsatellite instability (MSI), we obtained 4−7 biopsies from 39 CRCs followed by MSI analysis either using the Bethesda MSI evaluation system or Promega system with 5 mononucleotide markers.
Y. Eun, H. Chung, Y.C. Lee
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Material and Methods: To evaluate the extent of ITH in colorectal cancer (CRC) with microsatellite instability (MSI), we obtained 4−7 biopsies from 39 CRCs followed by MSI analysis either using the Bethesda MSI evaluation system or Promega system with 5 mononucleotide markers.
Y. Eun, H. Chung, Y.C. Lee
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American Journal of Nephrology, 2012
<b><i>Background:</i></b> Inflammation could be a causal factor in progression of chronic kidney disease. To date, there is convincing experimental and clinical evidence to support the notion that interleukin (IL)-17-producing T cells contribute to kidney injury in renal diseases.
Yang-Gyun, Kim +8 more
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<b><i>Background:</i></b> Inflammation could be a causal factor in progression of chronic kidney disease. To date, there is convincing experimental and clinical evidence to support the notion that interleukin (IL)-17-producing T cells contribute to kidney injury in renal diseases.
Yang-Gyun, Kim +8 more
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Cytokine, 2015
Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (PTC) and to assess the ...
Young Chan, Lee +7 more
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Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (PTC) and to assess the ...
Young Chan, Lee +7 more
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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
New England Journal of Medicine, 2012In this phase 2, randomized, double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the treatment of moderate-to-severe plaque psoriasis.We randomly assigned patients with a score of 12 or higher on the psoriasis area-and-severity ...
Kim A, Papp +10 more
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269 CRITICAL ROLE OF INTERLEUKIN-17 AND INTERLEUKIN-17 RECEPTOR SIGNALING IN TNBS-INDUCED COLITIS.
Journal of Investigative Medicine, 2006Inflammatory bowel diseases (IBD) are characterized by recurrent inflammation in the gastrointestinal tract. Infiltration of CD4+ lymphocytes and neutrophils is one of the predominant features in IBD. Recently, interleukin (IL)-23 and the downstream T-cell derived cytokine IL-17 have been found to be elevated in IBD patients. However, the role of IL-17
Z. Zhang +4 more
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Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis
Oncogene, 2020Interleukin-17 receptor D (IL-17RD), also known as similar expression to Fgf genes (SEF), is proposed to act as a signaling hub that negatively regulates mitogenic signaling pathways, like the ERK1/2 MAP kinase pathway, and innate immune signaling. The expression of IL-17RD is downregulated in certain solid tumors, which has led to the hypothesis that ...
Charlotte Girondel +10 more
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Interleukin-17 receptor D: An orphan receptor finds a home in the skin
Science Immunology, 2019Interleukin-17 receptor D (IL-17RD) heterodimerizes with IL-17RA to form a receptor selective for the cytokine IL-17A. (See the related Research Article by Su et al. )
Allison C. Billi, Johann E. Gudjonsson
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