Results 91 to 100 of about 5,291,137 (298)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Associação do gene IL-18 com Artrite Reumatóide em um estudo epidemiológico no estado de Santa Catarina: estudo caso-controle [PDF]

, 2009
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A doença auto-imune é causada por uma disfunção no sistema imunológico, onde as células de defesa do organismo reconhecem moléculas próprias como ...
Farias, Ticiana Della Justina
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Elevated serum IL-18 and IL-37 levels and their association with seizure burden in paediatric epilepsy

Frontiers in Immunology
BackgroundNeuroinflammation is increasingly recognized as a key contributor to epileptogenesis and epilepsy progression. Interleukin-18 (IL-18), a pro-inflammatory cytokine of the interleukin-1 family, has been implicated in seizure susceptibility ...
Marta Zawadzka, Jolanta Gleń, Przemysław Waszak, Marta Pietruszka, Anna Lemska, Magdalena Trzeciak, Maria Mazurkiewicz-Bełdzińska   +6 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Evaluation Of Stress, IL-18, And IL-22 Levels And Their Interrelationships In Patients With Seborrheic Dermatitis

Dermatology Practical & Conceptual
Introduction: Seborrheic dermatitis (SD) is a chronic inflammatory dermatosis with multifactorial pathogenesis. Cytokines such as IL-18 and IL-22 are implicated in inflammatory and stress-related pathways, but their roles in SD remain unclear ...
Lütfi Işık, Müzeyyen Gönül, Selda Pelin Kartal, Funda Güçel   +3 more
doaj   +1 more source

Clinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction

Journal of Inflammation Research, 2022
Xiaojuan Li, Tiewei Li, Geng Dong, Yulei Wei, Zhe Xu, Junmei Yang Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou ...
Li X, Li T, Dong G, Wei Y, Xu Z, Yang J
doaj  

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease [PDF]

, 2009
[[abstract]]Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid ...
Chen SY;Lei Wan;Huang YC;Sheu JJ;Lan YC;Lai CH;Lin CW;Chang JS;Tsai Y;Liu SP;Lin YJ;Tsai FJ
core  

[Interleukin-18].

Postepy higieny i medycyny doswiadczalnej, 2004
The paper describes the properties of interleukin-18 (IL-18), the cytokine originally designated as interferon-gamma inducing factor (IGIF): its production, structure and receptor (IL-18R) transmitting a signal to the cell. Moreover, it presents recent data on its biological activity.
Marek, Fol, Teresa, Gościcka
openaire   +1 more source