Results 11 to 20 of about 23,125,138 (369)

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

Cells, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Angelika Rose, Caroline von Spee-Mayer, Lutz Kloke, Kaiyin Wu, Anja Kühl, Philipp Enghard, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Jens Y. Humrich   +8 more
doaj   +4 more sources

Interleukin-2 therapy in patients with HIV infection [PDF]

, 2009
BACKGROUND Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
Aagaard, B., Abrams, D., Angus, B., Aragon, E., Arnaiz, J., Babiker, A., Borup, L., Clotet, B., Collins, G., Cooper, D. A., Cordwell, B., Darbyshire, J., Dodds, W., Dragsted, U., Emery, S., Fau, A., Fleck, S., Fox, L., Gey, D., Gordin, F., Grarup, J., Grijsen, M., Hengge, U., Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lane, H. C., Lange, J., Langebeek, N., Lopez, P., Losso, M. H., Lundgren, J., Lundgren, J. D., Lévy, Y., Matthews, C., Mitsuyasu, R., Mollerup, D., Neaton, J. D., Pearson, M., Phillips, A., Reilev, S., Reiss, P., Routy, J. P., Tambussi, G., Tillmann, K., van der Horst, C., Varea, S., Wentworth, D.   +49 more
core   +14 more sources

Effects of interleukin-2 in immunostimulation and immunosuppression

Journal of Experimental Medicine, 2019
Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol, P. Caudana, J. Paillet, E. Piaggio, G. Kroemer   +4 more
semanticscholar   +1 more source

Label-free, single molecule detection of cytokines using optical microcavities [PDF]

, 2007
Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be ...
Armani, Andrea M., Fraser, Scott E., Vahala, Kerry J.   +2 more
core   +1 more source

Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients

Cells, 2019
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS.
Alessia Capone, Manuela Bianco, Gabriella Ruocco, Marco De Bardi, Luca Battistini, Serena Ruggieri, Claudio Gasperini, Diego Centonze, Claudio Sette, Elisabetta Volpe   +9 more
doaj   +1 more source

Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice [PDF]

, 1998
In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice.
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +4 more sources

Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.

Blood Advances, 2017
Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults.
A. Hayden, Molly M. Lin, Sujin Park, M. Pudek, Marion Schneider, M. Jordan, A. Mattman, Luke Y. C. Chen   +7 more
semanticscholar   +1 more source

Production and characterisation of monoclonal antibodies specific for chicken interleukin-2 [PDF]

, 2001
Using genetic immunisation of mice, we produced antibodies against chicken interleukin-2 (ChIL-2), the first produced against a non-mammalian interleukin.
Hamblin, A, Kaiser, P, Rothwell, L
core   +1 more source

Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients

Allergology International, 2000
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis.
Toshiya Takahashi, Ken-ichi Maeda, Yoichi Nakamura, Yoshio Okano, Ning Ge, Saburo Sone   +5 more
doaj   +1 more source

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources