Results 11 to 20 of about 22,453,438 (395)

Interleukin-2 therapy in patients with HIV infection [PDF]

, 2009
BACKGROUND Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
Aagaard, B., Abrams, D., Angus, B., Aragon, E., Arnaiz, J., Babiker, A., Borup, L., Clotet, B., Collins, G., Cooper, D. A., Cordwell, B., Darbyshire, J., Dodds, W., Dragsted, U., Emery, S., Fau, A., Fleck, S., Fox, L., Gey, D., Gordin, F., Grarup, J., Grijsen, M., Hengge, U., Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lane, H. C., Lange, J., Langebeek, N., Lopez, P., Losso, M. H., Lundgren, J., Lundgren, J. D., Lévy, Y., Matthews, C., Mitsuyasu, R., Mollerup, D., Neaton, J. D., Pearson, M., Phillips, A., Reilev, S., Reiss, P., Routy, J. P., Tambussi, G., Tillmann, K., van der Horst, C., Varea, S., Wentworth, D.   +49 more
core   +8 more sources

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Journal of Experimental Medicine, 1998
Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens.
A. Thornton, E. Shevach
semanticscholar   +1 more source

Effects of interleukin-2 in immunostimulation and immunosuppression

Journal of Experimental Medicine, 2019
Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol, P. Caudana, J. Paillet, E. Piaggio, G. Kroemer   +4 more
semanticscholar   +1 more source

Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFκB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA [PDF]

, 1999
Interleukin-1 receptor-associated kinase, IRAK, has been shown to activate NFκB in response to interleukin-1. We have explored the involvement of IRAK in regulation of the interleukin-2 gene in the murine thymoma cell line EL4.NOB-1 by examining its ...
Greene, Catherine, O’Neill, Luke
core   +1 more source

Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2021
The rate of cognitive decline among patients with amnestic mild cognitive impairment (aMCI) varies, and it is thus crucial to accurately predict the probability of cognitive deterioration in patients with MCI.
Chih-Sung Liang, Chih-Sung Liang, Chia-Lin Tsai, Guan-Yu Lin, Jiunn-Tay Lee, Yu-Kai Lin, Yu-Kai Lin, Che-Sheng Chu, Che-Sheng Chu, Yueh-Feng Sung, Chia-Kuang Tsai, Ta-Chuan Yeh, Hsuan-Te Chu, Ming-Wei Su, Fu-Chi Yang, Fu-Chi Yang   +15 more
doaj   +1 more source

Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.

Blood Advances, 2017
Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults.
A. Hayden, Molly M. Lin, Sujin Park, M. Pudek, Marion Schneider, M. Jordan, A. Mattman, Luke Y. C. Chen   +7 more
semanticscholar   +1 more source

Label-free, single molecule detection of cytokines using optical microcavities [PDF]

, 2007
Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be ...
Armani, Andrea M., Fraser, Scott E., Vahala, Kerry J.   +2 more
core   +1 more source

Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies [PDF]

Pediatric Transplantation, 18(8):839-850, 2014, 2014
Interleukin-2 receptor antagonists (IL-2RA) are frequently used as induction therapy in liver transplant recipients to decrease the risk of acute rejection while allowing the reduction of concomitant immunosuppression. The exact association with the use of IL-2RA however is uncertain.
arxiv   +1 more source

Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients

Allergology International, 2000
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis.
Toshiya Takahashi, Ken-ichi Maeda, Yoichi Nakamura, Yoshio Okano, Ning Ge, Saburo Sone   +5 more
doaj   +1 more source

Interleukin-2 and leukemia [PDF]

Leukemia, 1998
Leukemia has been treated with chemotherapy for the past 40 years with only moderate success. A growing body of evidence suggests that by augmenting the immune system more effective results may be obtained. This is highlighted by T cell reinfusions resulting in durable remissions in patients with chronic myelogenous leukemia who have relapsed after an ...
M Goodman, Peter A. Cassileth, L Cabral
openaire   +3 more sources