Results 11 to 20 of about 22,558,942 (346)
Journal of Experimental Medicine, 1998 Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens.
A. Thornton, E. Shevach
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Effects of interleukin-2 in immunostimulation and immunosuppression
Journal of Experimental Medicine, 2019 Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol +4 more
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Structure-function relationships for the interleukin 2 receptor system
Memorias do Instituto Oswaldo Cruz, 1987 Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse.
Richard J. Robb
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mAbs, 2021 Simlukafusp alfa (FAP-IL2v, RO6874281/RG7461) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAP) and an IL-2 variant with a retained affinity for IL-2Rβγ > IL-2 Rβγ and abolished binding to IL-2 Rα.
Inja Waldhauer +28 more
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Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.
Blood Advances, 2017 Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults.
A. Hayden +7 more
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Interleukin-2 and leukemia [PDF]
Leukemia, 1998 Leukemia has been treated with chemotherapy for the past 40 years with only moderate success. A growing body of evidence suggests that by augmenting the immune system more effective results may be obtained. This is highlighted by T cell reinfusions resulting in durable remissions in patients with chronic myelogenous leukemia who have relapsed after an ...
M Goodman, Peter A. Cassileth, L Cabral
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The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings +2 more
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A versatile design platform for glycoengineering therapeutic antibodies
mAbs, 2022 Manipulation of glycosylation patterns, i.e., glycoengineering, is incorporated in the therapeutic antibody development workflow to ensure clinical safety, and this approach has also been used to modulate the biological activities, functions, or ...
Seth D. Ludwig +9 more
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Allergology International, 2000 Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis.
Toshiya Takahashi +5 more
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The Interleukin 2 Receptor [PDF]
Annual Review of Cell and Developmental Biology, 1988 Publisher Summary Although it was assumed initially that the various activities found in conditioned media were solely produced by lymphocytes, this idea was broadened subsequently to allow for activities that are produced by nonlymphoid cells, and the term cytokine is now sometimes used.
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