Results 201 to 210 of about 22,453,438 (395)

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

Advanced Science, EarlyView.
An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou, Li Li, Peidi Ren, Ting‐Ting Zhou, Fan He, Jialing Chen, Huimin Cai, Xiumin Han, Yao‐Dong Wu, Jiandong Li, Xiu‐Rong Li, Qiming Tan, Wenhui Li, Qi Chen, Nian‐Zhang Zhang, Xiuju He, Wei‐Gang Chen, Yanping Zhao, Jiwen Sun, Qian Zhang, Yan‐Tao Wu, Yingan Liang, Jie You, Guohai Hu, Xue‐Qi Tian, Sha Liao, Bao‐Quan Fu, Ao Chen, Xue‐Peng Cai, Huanming Yang, Jian Wang, Xin Jin, Xun Xu, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan   +35 more
wiley   +1 more source

Role of soluble interleukin-2 receptor (sIL-2R) as a predictor for severe dengue infection. [PDF]

Sci Rep
Singh AD, Saroch A, Pannu AK, Yadav AK, Sharda SC, Bhatia M, Kamboj K.   +6 more
europepmc   +1 more source

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

, 1988
E M Saltzman, R R Thom, J E Casnellie
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease. [PDF]

World J Gastroenterol
Andreu-Ballester JC, Hurtado-Marcos C, García-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, López-Chuliá F, Cuéllar C.   +10 more
europepmc   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Targeting interleukin-2-inducible T cell kinase ameliorates immune-mediated aplastic anemia. [PDF]

Cancer Immunol Immunother
Li W, Lian Y, Zhang L, Li R, Liang Q, Mao J, Qiu C, Li H, Huang K, Li Q, Shen Y, Yang F, Tian L, Xiao T, Gu S, Pan H, Gao Z, Zhao J, Fang L, Ge M, Yuan W, Chu Y, Shi J.   +22 more
europepmc   +1 more source

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

, 1984
Shimon Efrat, Raymond Kaempfer
openalex   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source

Comparative real-world outcomes of stage III melanoma patients treated with talimogene laherparepvec or interleukin 2. [PDF]

Ther Adv Med Oncol
Reitmajer M, Nanz L, Müller N, Leiter U, Amaral T, Aebischer V, Flatz L, Forschner A.   +7 more
europepmc   +1 more source