Results 71 to 80 of about 97,446,967 (252)

Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.

, 2002
Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines.
Howson, Joanna M M, Awomoyi, Agnes A, Agnes A Awomoyi (16176401), Arnaud Marchant (70401), Joanna M M Howson (3809950), Newport, M J, Keith P W J McAdam (16181906), Melanie Newport (4461202), McAdam, K P, Marchant, Arnaud, Blackwell, Jenefer M, Jenefer M Blackwell (10682454)   +11 more
core   +1 more source

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review [PDF]

, 2008
Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Kaptoge Stephen, Kaptoge, S., Lennon, L., Danesh, J, Lucy Lennon, Gudnason, Vilmundur, Stephen Kaptoge, Higgins Julian P. T, Wensley, F, Mann, Andrea G, Rumley, A., Sarwar, N, Wood, A, Ann Rumley, Vilmundur Gudnason, Danesh, J., Angleman, Sara B, Wood, A., Gudnason, V., Danesh John, Kaptoge, S, Wensley Frances, Wood, Angela, Lowe, G.D., John Danesh, Eiriksdottir, Gudny, Rumley, Ann, Angleman Sara B, Wensley, Frances, Gudnason Vilmundur, Sara B Angleman, Whincup Peter H, Kaptoge, Stephen, Gordon D O Lowe, Lennon Lucy, Sarwar, Nadeem, Higgins, JPT, Lennon, L, Higgins, J.P.T., Andrea G Mann, Peter H Whincup, Mann, AG, Lowe, GDO, Whincup, PH, Mann Andrea G, Whincup, P.H., Julian P T Higgins, Higgins, Julian PT, Lowe, Gordon DO, Angleman, S.B., Wensley, F., Sarwar, N., Mann, A.G., Eiriksdottir, G, Higgins, JP, Danesh, John, Sarwar Nadeem, Gudnason, V, Angleman, SB, Eiriksdottir, G., Lowe Gordon D. O, Angela Wood, Frances Wensley, Lowe, GD, Whincup, Peter H, Nadeem Sarwar, Eiriksdottir Gudny, Gudny Eiriksdottir, Wood Angela, Lennon, Lucy, Rumley Ann, Rumley, A   +71 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV₁.

, 2016
Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV1.
Ting Liu (45625), Fa-Ping Wang (3358667), Hui Mao (115181), Zhu Lan (3358673), Su-Yun Li (3358670)   +4 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

In Vitro Interleukin-1 and 2 Production and Interleukin 2 Receptor Expression in the Rhesus Monkey [PDF]

, 1996
Anti-human monoclonal antibodies were used to detect and quantify interleukins-1 and 2 and interleukin-2 receptor expression in peripheral blood mononuclear cells from a rhesus monkey. Interleukin-1 production could be induced by phorbol esters (PMA) and
Sonnenfeld, Gerald, Schaffar, Laurance, Schmitt, Didier A., Andre, Eric, Tkaczuk, Jean, Husson, David   +5 more
core  

Mathematical modeling of interleukin-27 induction of anti-tumor T cells response. [PDF]

, 2014
Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment.
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Xue-Feng Bai (333686), Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner, Kang-Ling Liao (535938), Avner Friedman (54903)   +9 more
core   +1 more source

Impact of angiotensin converting enzyme inhibition on post- coronary artery bypass interleukin 6 release [PDF]

, 2002
Background: Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti- inflammatory action.
Humphries, S.E., Rumley, A., Lowe, G.D., Montgomery, H.E., Sanders, J., Brull, D.J.   +5 more
core   +4 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Interleukin‑17A and Interleukin‑18 level in the blood serum of patients with different clinical course of Rosacea [PDF]

, 2018
Introduction. Rosacea is a common chronic dermatosis characterized by lesions of open areas of the skin (face) and torpidity to treatment. The objective of our study was to determine and analyze the content of proinflammatory cytokines – interleukin‑17A
Olha I. DENYSENKO, Maryna V. STOROZHUK
core   +2 more sources