Results 81 to 90 of about 97,446,967 (252)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2

, 1996
It is thought that Helicobacter pylori colonization of the gastric mucosa might stimulate the production of several cytokines, which might trigger and maintain the gastric inflammation associated with Helicobacter pylori infection.
TOMA A, PLEBANI, MARIO, BASSO D, Rugge, M., Plebani, M., NAVAGLIA F, Toma, A., Di Mario, F., RUGGE, MASSIMO, Navaglia, F., DIMARIO F, Scrigner, M., SCRIGNER M, Basso, D.   +13 more
core   +1 more source

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]

, 2012
Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Stefan Zeuzem, Herrmann, Eva, Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Rudloff, Ina, Bernd Kronenberger, Waidmann, Oliver, Albrecht Piiper, Pfeilschifter, Josef (Prof. Dr.), Piiper, Albrecht, Heiko Mühl, Filmann, Natalie, Ina Rudloff, Malte Bachmann, Eva Herrmann, Josef Pfeilschifter, Lisa Kapper, Bachmann, Malte, Brunner, Friederike, Kapper, Lisa, Mühl, Heiko, Natalie Filmann, Zeuzem, Stefan, Kronenberger Bernd, Brunner Friederike, Filmann Natalie, Kapper Lisa, Herrmann Eva, Zeuzem Stefan, Mühl Heiko, Rudloff Ina, Piiper Albrecht, Waidmann Oliver, Bachmann Malte, Pfeilschifter Josef   +35 more
core   +2 more sources

Role of Interleukin-18 in vascular injury: a new pharmacological target for the prevention of restenosis [PDF]

, 2006
Background: Studies in humans as well as in animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a strong predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization.
Grassia, Gianluca
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness

, 2004
Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin ...
MA Febbraio (9644273), Clinton Bruce (13064589), AL Carey (14534870), M Sacchetti (13701022), MJ Anderson (8365899), B Saltin (13701028), JA Hawley (9629840), DB Olsen (15871553)   +7 more
core  

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes [PDF]

, 2016
Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine interleukin-6 may impact on glucose homeostasis.
Imboden, Medea, Eze, Ikenna C, von Eckardstein, Arnold, Margaret W. Gerbase, Turk, Alexander, Ikenna C. Eze, Christian Schindler, Eze, Ikenna C., Kumar, Ashish, Probst-Hensch, Nicole, Daiana Stolz, Kronenberg, Florian, Medea Imboden, Adam, Martin, Künzli, Nino, Alexander Turk, Stolz, Daiana, Gerbase, Margaret W, Martin Adam, Nino Künzli, Gerbase, Margaret W., Florian Kronenberg, Nicole Probst-Hensch, Schindler, Christian, Arnold von Eckardstein, Ashish Kumar, von, Eckardstein A, Adam M, Turk A, Kronenberg F, Kumar, A,, Schindler, C, von Eckardstein A, Gerbase, MW, Kuenzli, N, Turk, A, Stolz, D, Schindler C, Eze, IC, Probst-Hensch N, Stolz D, Adam, M, Imboden M, Gerbase MW, Eze IC, Künzli N, Imboden, M, Kumar A   +47 more
core   +1 more source

Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Frontiers in Immunology, 2018
An understanding of interactions within the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL) has helped pave the way to novel immunotherapies that have enabled dormant and tumor-tolerant immune cells to be reactivated. The immunosuppressive
Jodi Chiu, Daniel M. Ernst, Armand Keating   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

ДИНАМИКА И ВЗАИМОСВЯЗИ СЫВОРОТОЧНЫХ КОНЦЕНТРАЦИЙ ИНТЕРЛЕЙКИНА-2, ИНТЕРЛЕЙКИНА-6, ФАКТОРА НЕКРОЗА ОПУХОЛИ АЛЬФА ПРИ ЦИРРОЗАХ ПЕЧЕНИ ВИРУСНОЙ ЭТИОЛОГИИ

, 2020
ELISA was used to assess serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in liver cirr- hosis patients referred to Child-Pugh Classes A, B, and C.
V. V. Zurabov, B. B. Fishman, С. Ш. Бутримова, Б. Б. Фишман, М. Э. Хапман, M. E. Hapman, M. A. Toneyeva, В. В. Зурабов, В. Е. Куликов, V. Ye. Kulikov, М. А. Тонеева, S. Sh. Butrimova   +11 more
core   +1 more source