Therapeutic potential of interleukin-21 in cancer [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is an immunostimulatory cytokine which belongs to the common gamma-chain family of cytokines. It plays an import role in the development, differentiation, proliferation, and activation of immune cells, in particular T and natural ...
Gheorghita Isvoranu +1 more
doaj +5 more sources
Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis [PDF]
Chinese Medical Journal, 2017 Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM.
Tao Liu +3 more
doaj +6 more sources
Interleukin-21 in Viral Infections. [PDF]
Int J Mol Sci, 2021 Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also
Asao H.
europepmc +5 more sources
Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21? [PDF]
Annals of Saudi Medicine, 2019 BACKGROUND: Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma.
Mohammed Al-Ayed +12 more
doaj +5 more sources
Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease [PDF]
Frontiers in Immunology, 2021 ObjectivesMultiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Mitsuhiro Akiyama +5 more
doaj +3 more sources
Interleukin‐21 in autoimmune and inflammatory skin diseases [PDF]
European Journal of Immunology, 2023 Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities.
Alberto Mesas‐Fernández +5 more
semanticscholar +4 more sources
A structural blueprint for interleukin-21 signal modulation [PDF]
Cell Reports, 2023 Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better
Gita C. Abhiraman +9 more
doaj +4 more sources
Biological Functions of Interleukin-21 and Its Role in Inflammation [PDF]
The Scientific World Journal, 2007 Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired ...
Martin Pelletier, Denis Girard
doaj +6 more sources
The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review [PDF]
International Journal of Inflammation, 2016 Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like periodontitis.
Archana Mootha +4 more
doaj +5 more sources
The effects of interleukin-21 in the biology of transplant rejection [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is a cytokine that plays a crucial role in regulating immune responses, affecting various immune cell types, including T cells, B cells, natural killer (NK) cells, and dendritic cells.
Xiandong Zeng +7 more
doaj +4 more sources