Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells [PDF]
Stem Cells International, 2022 Dysfunctions in adipose tissue cells are responsible for several obesity-related metabolic diseases. Understanding the process of adipocyte formation is thus fundamental for understanding these diseases.
Bruna Cristina Falavinha +7 more
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Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis [PDF]
Chinese Medical Journal, 2017 Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM.
Tao Liu +3 more
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Therapeutic potential of interleukin-21 in cancer [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is an immunostimulatory cytokine which belongs to the common gamma-chain family of cytokines. It plays an import role in the development, differentiation, proliferation, and activation of immune cells, in particular T and natural ...
Gheorghita Isvoranu +1 more
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A structural blueprint for interleukin-21 signal modulation [PDF]
Cell Reports, 2023 Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better
Gita C. Abhiraman +9 more
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The effects of interleukin-21 in the biology of transplant rejection [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is a cytokine that plays a crucial role in regulating immune responses, affecting various immune cell types, including T cells, B cells, natural killer (NK) cells, and dendritic cells.
Xiandong Zeng +7 more
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Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer [PDF]
Cells, 2019 Pancreatic ductal adenocarcinoma (PDAC) displays a marked fibro-inflammatory microenvironment in which infiltrated immune cells fail to eliminate the tumor cells and often—rather paradoxically—promote tumor progression.
Alica Linnebacher +11 more
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Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential [PDF]
Cells, 2023 Brain tumors represent a heterogeneous group of neoplasms involving the brain or nearby tissues, affecting populations of all ages with a high incidence worldwide.
Alberto Repici +9 more
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Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease [PDF]
Frontiers in Immunology, 2021 ObjectivesMultiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Mitsuhiro Akiyama +5 more
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Role of Hemin in the Immune Response of T Follicular Helper Lymphocytes Expressing T-Cell Immunoreceptor with Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Domains, Programmed Cell Death-1, and Interleukin-21 in Allo-Auto Positive and Negative Thalassemia [PDF]
Journal of Blood Medicine, 2023 Betty Agustina Tambunan,1– 3 I Dewa Gede Ugrasena,3,4 Aryati2,3 1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya,
Tambunan BA, Ugrasena IDG, Aryati
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Decreased Serum Levels of Interleukin-4 and Interleukin-21 in New Pemphigus Vulgaris Patients, but Not Chronic Patients With Inactive Disease Compared to Healthy Controls [PDF]
Dermatology Practical & Conceptual, 2021 Background: Pemphigus is a rare group of autoimmune blistering diseases with unknown etiology and unclear pathogenesis. Pemphigus vulgaris (PV) is the most common subtype, and is characterized by ulcerations or flaccid blisters on mucous membranes and on
Pegah Shahbazian +7 more
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