Results 181 to 190 of about 3,093,388 (334)

Impact of Hemin on Interleukin-21 Levels and Plasma Cells in Transfusion-Dependent Thalassemia with Positive and Negative Allo-Autoantibody. [PDF]

Int J Gen Med, 2023
Tambunan BA, Ugrasena IDG, Aryati A.
europepmc   +1 more source

Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells [PDF]

, 2010
Anita Parmigiani, Maria Pallin, Helena Schmidtmayerova, Mathias G. Lichtenheld, Savita Pahwa   +4 more
openalex   +1 more source

The Impact Of Interleukin-21 On Intestinal Inflammation During Health And Disease [PDF]

, 2014
The intestinal environment is extremely complex due to the dynamic interactions between host cells and luminal contents. The immune cells located in the intestine are responsible for sensing and responding to intestinal pathogens as well as maintaining ...
Poholek, Catherine
core   +1 more source

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Advanced Healthcare Materials, EarlyView.
Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono   +11 more
wiley   +1 more source

Design and Characterization of Novel Antibody-Cytokine Fusion Proteins Based on Interleukin-21. [PDF]

Antibodies (Basel), 2022
Di Nitto C, Neri D, Weiss T, Weller M, De Luca R.   +4 more
europepmc   +1 more source

Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4 ⁺ T Cells [PDF]

, 2021
Jernej Pušnik, Stephanie Fischinger, Ulf Dittmer, Stefan Eßer, Marit J. van Gils, Rogier W. Sanders, Galit Alter, Hendrik Streeck   +7 more
openalex   +1 more source

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice [PDF]

, 2011
Dominik Jauch, M. Martin, Gabriela Schiechl, Rebecca Kesselring, Hans J. Schlitt, Edward K. Geissler, Stefan Fichtner‐Feigl   +6 more
openalex   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56^dimCD16^bright natural killer cells during kidney allograft antibody-mediated rejection showing a new link between adaptive and innate humoral allo-immunity. [PDF]

Kidney Int, 2023
Bailly E, Macedo C, Ossart J, Louis K, Gu X, Ramaswami B, Bentlejewski C, Zeevi A, Randhawa P, Lefaucheur C, Metes D.   +10 more
europepmc   +1 more source