Results 201 to 210 of about 61,069,248 (252)

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Interleukin‐21 in chronic inflammatory diseases

BioFactors, 2013
Interleukin‐21 (IL‐21), a cytokine produced by various subsets of activated CD4+ T cells, regulates multiple innate and adaptive immune responses. Indeed, IL‐21 controls the proliferation and function of CD4+ and CD8+ T lymphocytes, drives the differentiation of B cells into memory cells and Ig‐secreting plasma cells, enhances the activity of natural ...
Sarra, M, PALLONE, FRANCESCO, MONTELEONE, GIOVANNI   +2 more
openaire   +4 more sources

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Nature Medicine, 2009
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice.
Caruso, R, Botti, E, Sarra, M, Esposito, M, Stolfi, C, Diluvio, L, Giustizieri, ML, Pacciani, V, Mazzotta, A, Campione, E, MacDonald, TT, CHIMENTI, SERGIO, PALLONE, FRANCESCO, COSTANZO, ANTONIO, MONTELEONE, GIOVANNI   +14 more
core   +5 more sources

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Measurement of Interleukin‐21

Current Protocols in Immunology, 2007
AbstractThis unit describes three procedures for measurement of interleukin‐21 (IL‐21). The first employs the use of an antibody sandwich ELISA. An alternative procedure measures proliferative responses of T cells to a combination of IL‐21 and IL‐15 using CFSE.
Rong, Zeng, Rosanne, Spolski, Warren J, Leonard   +2 more
openaire   +2 more sources

Immune Modulation with Interleukin‐21

Annals of the New York Academy of Sciences, 2009
Interleukin 21 (IL‐21) is produced by activated CD4+ T cells. The IL‐21R shares the common receptor gamma‐chain with IL‐2, IL‐4, IL‐7, IL‐9, and IL‐15, is widely expressed on immune cells, and mediates a variety of effects on the immune system. IL‐21 enhances the proliferation, antigen‐induced activation, clonal expansion, IFN‐γ production, and ...
Neela S, Bhave, William E, Carson
openaire   +2 more sources

Role of Interleukin-21 in Inflammation and Allergy

Inflammation & Allergy-Drug Targets, 2007
Interleukin-21 (IL-21) is a newly described cytokine, produced by activated CD4+ T cells. Since the discovery in 2000, IL-21 has been the object of intensive research because of its homology to IL-2, IL-4 and IL-15, and its ability to modulate both innate and adaptive immune responses.
Fina D., FANTINI, MASSIMO CLAUDIO, PALLONE, FRANCESCO, MONTELEONE, GIOVANNI   +3 more
openaire   +5 more sources

Interleukin-21 and Cancer Therapy

2009
Interleukin-21 (IL-21) is a pleiotropic cytokine structurally similar to IL-2 and IL-15 but with important distinctions in its biological properties. IL-21 is mainly secreted by activated CD4+ T cells, NKT cells, and follicular T helper (Tfh) cells. The IL-21 receptor is expressed physiologically on lymphoid tissues and peripheral blood mononuclear ...
Davis, Ian D., Skak, Kresten, Hunder, Naomi, Smyth, Mark J., Sivakumar, Pallavur V.   +4 more
openaire   +3 more sources