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Interleukin-21 in Immune and Allergic Diseases
Inflammation & Allergy-Drug Targets, 2012Interleukin-21 (IL-21), a cytokine produced by various subsets of activated CD4+ T cells, plays a major role in the control of innate and adaptive immune responses. IL-21 biological activity is mediated by binding of the cytokine to a heterodimeric receptor, composed of a specific subunit, termed IL-21 receptor (IL-21R), and the common γ-chain, that is
Sarra, M +3 more
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Targeting interleukin-21 in inflammatory diseases
Expert Opinion on Therapeutic Targets, 2011IL-21, a new member of the type 1 cytokine superfamily, is produced by various subsets of CD4(+) T cells and binds to a composite receptor that consists of a specific receptor, termed IL-21 receptor and the common γ-chain subunit. Initially considered to be a critical regulator of T and B cell function, IL-21 is now known to regulate the activity of ...
Sarra, M +3 more
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Targeting interleukin-21 in rheumatoid arthritis
Molecular Biology Reports, 2010Interleukin-21 (IL-21) is a new member of the type I cytokine superfamily, which binds to a composite receptor that consists of a private receptor (IL-21R) and the common cytokine receptor γ chain. Recently, increasing evidence has shown that IL-21 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases because of its pro ...
Feng-Lai, Yuan +8 more
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Optimization of interleukin-21 immunotherapeutic strategies
Journal of Theoretical Biology, 2007The recently discovered interleukin-21 (IL-21) shows strong tumor attenuation in preclinical studies, and is considered a promising cancer immunotherapy agent. Yet, to exploit its potential, therapeutic strategies must be designed to achieve adequate balance between several conflicting aspects.
Cappuccio, Antonio +2 more
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Gene, 2014
Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production.
Yan Lan +4 more
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Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production.
Yan Lan +4 more
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Targeting Interleukin-21 in Immune-Mediated Pathologies
Current Drug Targets, 2010Interleukin (IL)-21, a cytokine mostly produced by activated CD4+ T cells, has been reported to play an important role in the tissue-damaging immune response in various organs. This pathogenic effect is strictly linked to the ability of IL-21 to control the functional activities of multiple immune and non-immune cells. For instance, IL-21 regulates the
Sarra, M +3 more
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Interleukin 21: combination strategies for cancer therapy
Nature Reviews Drug Discovery, 2008In the past 20 years researchers have attempted to activate the host immune defence system to kill tumour cells and eradicate cancer. In some cases, the response of patients to immunotherapy has been extremely successful; however, other trials have shown disappointing results, and so there is a clear need for more effective therapies that can ...
Skak, Kresten +4 more
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Involvement of interleukin‐21 in the pathophysiology of aplastic anemia
European Journal of Haematology, 2015AbstractObjectiveRecently enhanced T‐helper type 17 (Th17) immune responses and deficient CD4+CD25hiFoxP3+ regulatory T cells (Tregs) have been reported in acquired aplastic anemia (AA). Interleukin‐21 (IL‐21), a CD4+ T‐cell‐derived proinflammatory cytokine, modulates the balance between Th17 cells and Tregs.
Jizhou, Zhang +7 more
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Interleukin-21: biology and application to cancer therapy
Expert Opinion on Biological Therapy, 2008IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms.
David J, Andorsky, John M, Timmerman
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Interleukin 21: A Key Player in Lymphocyte Maturation
Critical Reviews in Immunology, 2004The common gamma chain family of cytokine receptors plays a plethora of roles during the early development, activation, and terminal differentiation of the lymphocyte lineages. The most recently identified member of this family, the IL-21R, is expressed to varying degrees on B, T lymphocytes, and natural killer (NK) cells, whereas IL-21, is reportedly ...
Stephen L, Nutt +3 more
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