Results 31 to 40 of about 528,114 (310)

Interleukin-21 receptor might be a novel therapeutic target for the treatment of rheumatoid arthritis [PDF]

, 2014
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the synovial inflammation of the joints. Various cells and cytokines have been identified that may contribute to RA pathology. Interleukin (IL)-21 is a proinflammatory
Andersson, Arnett, Asao, Bagheri, Bagheri, Boghozian, Boissier, Brandt, Carbone, Caruso, Christodoulou, Dolff, Fantini, Feldmann, Frleta, Fröhlich, Gabriel, Geri, Grebowska, Herber, Hong, Jang, Jüngel, Kiani, Korn, Lebre, Lee, Leonard, Leonard, Li, Li, Liu, Liu, McInnes, Monteleone, Monteleone, Niu, Nurieva, Nurieva, Parrish-Novak, Parrish-Novak, Sandoo, Singh, Son, Spolski, Strengell, Terrier, Van Belle, Vieira, Vollmer, Young   +50 more
core   +1 more source

Elevated circulating levels of IL-21 and IL-22 define a cytokine signature profile in type 2 autoimmune hepatitis patients

Annals of Hepatology, 2016
Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to
Pablo Thomas-Dupont, José M. Remes-Troche, Irma Y. Izaguirre-Hernández, Luis A. Sánchez-Vargas, Mathywz de J. Maldonado-Rentería, Karina G. Hernández-Flores, Aldo Torre, Elidé Bravo-Sarmiento, Héctor Vivanco-Cid   +8 more
doaj   +1 more source

Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study [PDF]

, 2014
Background Despite the positive impact of targeted therapies on metastatic renal cell carcinoma (mRCC), durable responses are infrequent and an unmet need exists for novel therapies with distinct mechanisms of action.
Bhatia, Shailender, Brendan, Ernstoff, Marc S, Heath, Elisabeth I, Jeremy, Kelly, Michael, Miller, Wilson H, Jr, Naomi, Puzanov, Igor, Quinn, David I, Rachel, Sonia, Thomas, Thompson, John A, VanVeldhuizen, Peter   +15 more
core   +4 more sources

Interleukin-21 in cancer immunotherapy [PDF]

OncoImmunology, 2012
Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer.
Stolfi, C, PALLONE, FRANCESCO, Macdonald, T, MONTELEONE, GIOVANNI   +3 more
openaire   +3 more sources

Aberrant expansion of follicular helper T cell subsets in patients with systemic lupus erythematosus

Frontiers in Immunology, 2022
ObjectiveSystemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by multiple autoantibodies, resulting in multiple organ and tissue damages.
Xin Jin, Jia Chen, Jian Wu, Ying Lu, Baohua Li, Wenning Fu, Wei Wang, Dawei Cui   +7 more
doaj   +1 more source

IL-21 receptor expression in human tendinopathy [PDF]

, 2014
The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role.
Campbell, Abigail L., Fazzi, Umberto G., Kerr, Shauna C., Leach, William J., Millar, Neal L., Murrell, George A.C., Reilly, James H., Rooney, Brian P., Smith, Nicola C.   +8 more
core   +2 more sources

Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases [PDF]

BMC Endocrine Disorders, 2013
The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymorphisms of the IL-21 and IL-21R are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITDs, among a ...
Zhang, Jian, Xiao, Wan Xia, Zhu, Yuan Feng, Muhali, Fatuma Said, Xiao, Ling, Jiang, Wen Juan, Shi, Xiao Hong, Zhou, Lian Hua, Zhang, Jin An   +8 more
openaire   +2 more sources

IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer

Frontiers in Oncology, 2021
Regulatory T cells (Tregs) are immunosuppressive cells involved in antitumor immunity. However, the regulation of Treg generation by inflammation in the tumor microenvironment has not been carefully investigated.
Yi Zhao, Yi Zhao, Zhiyu Zhang, Zhiyu Zhang, Wenbin Lei, Wenbin Lei, Yi Wei, Yi Wei, Renqiang Ma, Renqiang Ma, Yihui Wen, Yihui Wen, Fanqin Wei, Fanqin Wei, Jun Fan, Yang Xu, Yang Xu, Lin Chen, Lin Chen, Kexing Lyu, Kexing Lyu, Hanqing Lin, Hanqing Lin, Weiping Wen, Weiping Wen, Wei Sun, Wei Sun   +26 more
doaj   +1 more source

Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression [PDF]

, 2015
The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).
Cahn, Pedro, Falivene, Juliana, Figueroa, María Inés, Gherardi, Maria Magdalena, Ghiglione, Yanina Alexandra, Giavedoni, Luis D., Holgado, María Pía, Laufer, Natalia Lorna, Maeto, Cynthia Alejandra, Ruiz, Maria Julia, Salomon, Horacio Eduardo, Socías, María Eugenia, Sued, Omar Gustavo, Turk, Gabriela Julia Ana   +13 more
core   +1 more source

Modulation of tryptophan/serotonin pathway by probiotic supplementation in human immunodeficiency virus-positive patients: preliminary results of a new study approach [PDF]

, 2017
Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals.
Cavallari, Eugenio Nelson, Ceccarelli, Giancarlo, Corano Scheri, Giuseppe, D'Ettorre, Gabriella, DE GIROLAMO, Gabriella, Giustini, Noemi, Laghi, Luca, Mastrangelo, Andrea, Najafi Fard, Saeid, Pinacchio, Claudia, Schietroma, Ivan, Serafino, Sara, Statzu, Maura, Vullo, Annamaria, Vullo, Vincenzo   +14 more
core   +3 more sources