Results 211 to 220 of about 576,409 (261)

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Interleukin-22 receptor 1-mediated stimulation of T-type Ca²⁺ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway. [PDF]

Cell Commun Signal
Cai H, Chen S, Sun Y, Zheng T, Liu Y, Tao J, Zhang Y.   +6 more
europepmc   +1 more source

Interleukin-22: Immunobiology and Pathology [PDF]

Annual Review of Immunology, 2015
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung,
Jarrod Dudakov, Alan M Hanash, Marcel van den Brink   +2 more
exaly   +3 more sources

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Role of interleukin-22 in tuberculosis patients

Journal of Basic and Clinical Physiology and Pharmacology, 2022
Abstract Objectives Disease progression of tuberculosis (TB) depends on the balance between the microorganism’s virulence and the host defense systems (mainly T cell-mediated immune response).
Shruti Gupta, Mithu Banerjee, Kavya Gauba, Prasenjit Mitra, Jyoti Shekhawat, Nishant Chauhan, Hemant Borana, Mahadev Rao, Dharmveer Yadav, Praveen Sharma   +9 more
openaire   +2 more sources

Biology of interleukin-22

Seminars in Immunopathology, 2010
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and ...
Kerstin, Wolk, Ellen, Witte, Katrin, Witte, Katarzyna, Warszawska, Robert, Sabat   +4 more
openaire   +2 more sources

Interleukin-22

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Interleukin (IL)-22 is a member of the human type I interferon family, which includes IL-10. IL-22 has the potential to interact with IL-10 because it binds to the IL-10R2c chain with IL-22R1 in its receptor complex. Binding can be blocked by the soluble receptor, IL-22 binding protein (IL-22BP). We hypothesize that IL-22 and
Hayley A. Whittington, Lynne Armstrong, Kay M. Uppington, Ann B. Millar   +3 more
openaire   +1 more source

Temporal expression of interleukin‐22, interleukin‐22 receptor 1 and interleukin‐22‐binding protein during experimental periodontitis in rats

Journal of Periodontal Research, 2017
Background and ObjectiveInterleukin‐22 (IL‐22), mainly produced by CD4+ T‐helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri‐implantitis and chronic rhinosinusitis with nasal polyps.
S. Pan, D. Yang, J. Zhang, Z. Zhang, H. Zhang, X. Liu, C. Li   +6 more
openaire   +2 more sources