Results 81 to 90 of about 71,336,553 (298)
, 2022 The Toll/interleukin-1 receptor (TIR) domains are key innate immune signalling modules. Here, we present the crystal structure of the TIR domain of human interleukin-1 receptor 10 (IL-1R10), also called interleukin 1 receptor accessory protein like 2. It
Surekha Nimma +11 more
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Interleukin-22 and its crystal structure
, 2006 Interleukin-22 (IL-22) is a cytokine that regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes ...
Ferreira Junior, Josii Ribamar +9 more
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IL21R (interleukin 21 receptor) [PDF]
, 2009 Review on IL21R (interleukin 21 receptor), with data on DNA, on the protein encoded, and where the gene is ...
Fabbi, M, Ferrini, S, S Ferrini, M Fabbi
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Activation of the aryl hydrocarbon receptor in vivo primes human T cells for interleukin 22 production and inhibits Th17 cells [PDF]
Annals of the Rheumatic Diseases, 2010 Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating dioxin effects, favour Th17 cell differentiation and exacerbate autoimmunity in mice. The authors investigated how AHR ligands affect human T cell polarisation. The high affinity and stable AHR ligand dioxin as well as the natural AHR ligand …
J-M Ramirez +8 more
openaire +1 more source
, 2019 ## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Supplementary Figures from the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti ...
McCulloch, Laura
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IL21R (interleukin 21 receptor) [PDF]
, 2012 Review on IL21R (interleukin 21 receptor), with data on DNA, on the protein encoded, and where the gene is ...
Fabbi, M, Ferrini, S
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source
Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor [PDF]
, 2012 The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
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