Results 101 to 110 of about 615,879 (297)

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

IL22/IL-22R pathway induces cell survival in human glioblastoma cells.

PLoS ONE, 2015
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in
Hussein Akil, Amazigh Abbaci, Fabrice Lalloué, Barbara Bessette, Léa M M Costes, Linda Domballe, Sandrine Charreau, Karline Guilloteau, Lucie Karayan-Tapon, François-Xavier Bernard, Franck Morel, Marie-Odile Jauberteau, Jean-Claude Lecron   +12 more
doaj   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immune homeostasis in sub-health mice based on the CD4+-Th17/Treg immunity axis

Food Science and Human Wellness
The aim of this study was to investigate the role of Dendrobium officinale crude polysaccharides (DOPS) and D. officinale purified polysaccharides (DOPS100) in attenuating immune dysfunction in subfertile mice.
Bo Li, Zehua Zhang, Linnan Zhang, Xinglishang He, Haoru Guan, Ning Wang, Yingjie Dong, Mei Rong, Jiujie Jia, Tingting Chen, Zhiyuan Li, Guiyuan Lü, Suhong Chen   +12 more
doaj   +1 more source

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D. [PDF]

, 2014
Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis.
Agak, George W, Elashoff, David, Garbán, Hermes J, Kim, Jenny, Kim, Myung-Hwa, Krutzik, Stephan R, Nobe, Jennifer, Qin, Min, Tristan, Grogan R   +8 more
core  

An evaluation of risk factors for major adverse cardiovascular events during tocilizumab therapy [PDF]

, 2015
Objective: To evaluate associations between lipid levels, inflammation, and rheumatoid arthritis (RA) disease activity, at baseline and during treatment, with the risk of major adverse cardiovascular events (MACE) in tocilizumab‐treated patients with RA.
Bathon, Joan M., Giles, Jon T., Klearman, Micki, Lee, Janet S., Musselman, David, Pavlov, Andrey, Rao, Vijay U., Sattar, Naveed   +7 more
core   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take

Gut Pathogens
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira   +2 more
doaj   +1 more source

Effect of Plectranthus Amboinicus Extract on BUN and Creatinine Levels and Cellular Response Proinflammatory Factors TNF-α and IL-1β on Gout Arthritis Patients [PDF]

, 2014
The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicus applied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized control group design.
Martini, S. (Santi), Muniroh, L. (Lailatul), Nindya, T. S. (Triska), Solfaine, R. (Rondius)   +3 more
core   +2 more sources