Results 111 to 120 of about 71,336,553 (298)

Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take

Gut Pathogens
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (
Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira   +2 more
doaj   +1 more source

Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immune homeostasis in sub-health mice based on the CD4+-Th17/Treg immunity axis

Food Science and Human Wellness
The aim of this study was to investigate the role of Dendrobium officinale crude polysaccharides (DOPS) and D. officinale purified polysaccharides (DOPS100) in attenuating immune dysfunction in subfertile mice.
Bo Li, Zehua Zhang, Linnan Zhang, Xinglishang He, Haoru Guan, Ning Wang, Yingjie Dong, Mei Rong, Jiujie Jia, Tingting Chen, Zhiyuan Li, Guiyuan Lü, Suhong Chen   +12 more
doaj   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.

Asian Pacific journal of allergy and immunology, 2012
We sought to determine whether the aryl hydrocarbon receptor (AhR) and interleukin (IL)-22 may be involved in the pathogenesis of the peripheral blood mononuclear cells (PBMCs) in allergic asthmatic patients and whether their expression may be related to the severity of the disease.Blood samples were obtained from each subject with allergic asthma (n ...
Jing, Zhu, Yong, Cao, Kaiyan, Li, Zhengyun, Wang, Peng, Zuo, Weining, Xiong, Yongjian, Xu, Shengdao, Xiong   +7 more
openaire   +1 more source

Real‐World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA). Methods This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan   +28 more
wiley   +1 more source

Identification of SNPsin Interferon Gamma, Interleukin-22, and Their Receptors and Associations with Health and Production-Related Traits in Canadian Holstein Bulls

Animal Biotechnology, 2011
Genetic variants in a number of immunoregulatory genes have been previously associated with health and production traits in dairy cattle. Therefore, in the following study, the genes coding interferon gamma (IFNG), IFNG receptor 1 and 2 domains, interleukin-22 (IL22), and IL22 receptor alpha 1, were investigated for single nucleotide polymorphisms ...
Chris P, Verschoor, Sameer D, Pant, Graham A, Biggar, Flavio S, Schenkel, Bhawani S, Sharma, Niel A, Karrow   +5 more
openaire   +2 more sources

Protease‐Activated Theranostic Nanomedicine for Endometriosis Treatment

Advanced Functional Materials, EarlyView.
Endometriosis is a chronic gynecological disorder that affects a substantial proportion of reproductive‐aged women. In this study, we identify aberrant overexpression of matrix metalloproteinase‐9 (MMP‐9) in endometriotic lesions and develop a novel multifunctional nanomedicine that integrates MMP‐9‐targeted therapy, ratiometric photoacoustic (PA ...
Panangattukara Prabhakaran Praveen Kumar, Tae Hoon Kim, Hossein Hosseinirad, Maggie Lee, HyeJoo An, Bruce A. Lessey, Daniel Hanavi, Jung‐Ho Shin, Jae‐Wook Jeong, Taeho Kim   +9 more
wiley   +1 more source

IL22/IL-22R pathway induces cell survival in human glioblastoma cells.

PLoS ONE, 2015
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in
Hussein Akil, Amazigh Abbaci, Fabrice Lalloué, Barbara Bessette, Léa M M Costes, Linda Domballe, Sandrine Charreau, Karline Guilloteau, Lucie Karayan-Tapon, François-Xavier Bernard, Franck Morel, Marie-Odile Jauberteau, Jean-Claude Lecron   +12 more
doaj   +1 more source

Interleukin-22 and interleukin-22 binding protein signaling axis influences intubation status in trauma [PDF]

Background: Interleukin-22 is a cytokine involved in mucosal immunity, whereas interleukin-22 binding protein is a soluble receptor that can potently block interleukin-22.
Shenk, Megan, Smith, Alison, Pociask, Derek, Kolls, Jay K., Anderson, Augustus E., Broome, Jacob, Albuck, Aaron L., Noguera, Valeria, Tatum, Danielle, Duchesne, Juan, Bojanowski, Christine M., Covey, Wid, Jackson-Weaver, Olan, Taghavi, Sharven   +13 more
core   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source