Results 131 to 140 of about 71,336,553 (298)

INI846281 Supplemental Material - Supplemental material for Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease

, 2020
Supplemental material, INI846281 Supplemental Material for Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease by Kari Ann Shirey, Wendy Lai, Lindsey J Brown, Jorge C G Blanco,
Yajing Wang (447120), Kari Ann Shirey (2902034), Wendy Lai (432776), Robert Beadenkopf (6308528), Stefanie N Vogel (6246032), Stefanie Vogel (1234251), Jorge C G Blanco (8337162), Greg A Snyder (8337165), Lindsey J Brown (8337159)   +8 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Targeting interleukin-22 for cancer therapy

Human Vaccines & Immunotherapeutics, 2018
Interleukin-22 (IL-22) is a member of IL-10 family of cytokines. IL-22 induces proliferative and anti-apoptotic signaling pathways and production of anti-microbial molecules that enhance tissue regeneration and host defense.
Anamarija Markota, Stefan Endres, Sebastian Kobold   +2 more
doaj   +1 more source

Structure and function of interleukin-22 and other members of the interleukin-10 family

, 2010
The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-lambda s (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in ...
Igor Polikarpov, Trivella, Daniela Barretto Barbosa, Renauld, Jean-Christophe, Renauld, Jean Christophe, Jean-Christophe Renauld, Ferreira-Junior, Jose Ribamar, José Ribamar Ferreira-Júnior, Laure Dumoutier, Daniela Barretto Barbosa Trivella, Barbosa Trivella, Daniela Barretto, Polikarpov, Igor, Dumoutier, Laure, Ferreira Júnior, José Ribamar   +12 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity

EMBO Molecular Medicine
Short-chain fatty acids (SCFA) protect against central nervous system (CNS) autoimmunity, but the receptor-mediated mechanisms underlying these effects remain poorly understood, limiting their therapeutic exploitation.
Bojan Jevtić, Milica Lazarević, Goran Stegnjaić, Suzana Stanisavljević, Ivan Pilipović, Neda Nikolovski, Zorana Milosavljević, Miljana Momčilović, Ivan Koprivica, Natalija Jonić, Dragica Mićanović, Nataša Radulović, Maša Marković, Ksenija Mirković, Danijela Mišić, Uroš Gašić, Filip Nikolić, Nikola Veselinović, Henrike Körner, Lukas Grimm, Dmitri Lodygin, Alexander Flügel, Graeme Fraser, Tamara Saksida, Mirjana Dimitrijević, Ivana Stojanović, Đorđe Miljković   +26 more
doaj   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Genetic susceptibility to rheumatoid arthritis: a meta-analysis of interleukin-10 and protein tyrosine phosphatase non-receptor type 22 gene variants

Egyptian Rheumatology and Rehabilitation
Objectives The association between interleukin-10 (IL-10) and protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been implicated in immune regulation and autoimmune risk.
Sharon Benita Stephen, Senthil P, Dapkupar Wankhar, Muthuselvi M, Gowtham Kumar Subbaraj   +4 more
doaj   +1 more source

Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis

Frontiers in Immunology
IntroductionColitis is an inflammatory bowel disease (IBD) characterized by immune cell dysregulation and alterations in the gut microbiome. In our previous report, we showed a natural product in cruciferous vegetables and ligand of the aryl hydrocarbon ...
Chandani Mitchell, Shanieka Staley, Michal Claire Williams, Archana Saxena, Raymond Bogdon, Kasie Roark, Michele Hailey, Kathryn Miranda, William Becker, Nicholas Dopkins, Maria Marjorette Pena, Kristen M. Hogan, Maredith Baird, Kiesha Wilson, Prakash Nagarkatti, Mitzi Nagarkatti, Philip Brandon Busbee   +16 more
doaj   +1 more source