Results 121 to 130 of about 71,336,553 (298)

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex [PDF]

Journal of Biological Chemistry, 2001
Sergei V. Kotenko, Lara S. Izotova, Olga V. Mirochnitchenko, Elena Esterova, Harold Dickensheets, Raymond P. Donnelly, Sidney Pestka   +6 more
openaire   +1 more source

Role of IL-38 and Its Related Cytokines in Inflammation

Mediators of Inflammation, 2015
Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor
Xianli Yuan, Xiao Peng, Yan Li, Mingcai Li   +3 more
doaj   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-Driven Interleukin-22 Production

Cellular and Molecular Gastroenterology and Hepatology
Colorectal cancer often requires surgical resection of the tumor and an anastomosis. Anastomotic leakage (AL) occurs in 2.8-30% of patients which increases postoperative morbidity and complications. The preoperative microbiome composition is implicated in AL.
Vasiliki Bantavi, Laura Gloeck, Patrick Leven, Konstantina Zafeiropoulou, Olaf Welting, Hilal Sengül, Patrik Efferz, Bianca Schneiker, Timothy Ryan McCulloch, Christoph Wilhelm, Sandra Blaess, Anneke Fuss, Joop L.M. Konsten, Jan Stoot, Nicole D. Bouvy, Joep P.M. Derikx, Bruno Sovran, Wouter J. de Jonge, Sven Wehner   +18 more
openaire   +2 more sources

An engineered probiotic for diagnosis and mucosal healing in inflammatory bowel disease

Cell Reports
Summary: Early diagnosis and timely treatment of inflammatory bowel disease (IBD) are critical to limit disease progression, yet integrated diagnostic-therapeutic strategies remain limited.
Yu Zhao, Yujie Sun, Xiaofeng Zhu, Wulong Hu, Sifeng Chen, Guofan Peng, Shichao Yang, Ding Ma, Xiayu Mao, Shengen Yi, Li Tian, Kang Han, Xiongzhuo Tang, Jin Hai Zheng, Jun Zhou   +14 more
doaj   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration

Journal of Cancer, 2013
Tissue regeneration is a critical component of organ maintenance. The ability of lymphocytes to kill pathogen-infected cells has been well-studied. However, the necessity for lymphocytes to participate in reconstruction of destroyed tissues has not been ...
Pawan Kumar, Kamalakannan Rajasekaran, Jeanne M Palmer, Monica S Thakar, Subramaniam Malarkannan
doaj  

IL-22: A key inflammatory mediator as a biomarker and potential therapeutic target for lung cancer

Heliyon
Lung cancer, one of the most prevalent cancers worldwide, stands as the primary cause of cancer-related deaths. As is well-known, the utmost crucial risk factor contributing to lung cancer is smoking. In recent years, remarkable progress has been made in
Ling Xu, Peng Cao, Jianpeng Wang, Peng Zhang, Shuhui Hu, Chao Cheng, Hua Wang   +6 more
doaj   +1 more source