Results 171 to 180 of about 530,938 (302)

Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. [PDF]

open access: yesCell Rep, 2023
Jacobse J   +24 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

Lichen planus onset during interleukin 23 blockade for treatment of psoriasis. [PDF]

open access: yesJAAD Case Rep
Abbas A   +4 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

open access: yesAdvanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu   +7 more
wiley   +1 more source

Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis. [PDF]

open access: yesJ Neuroinflammation, 2023
Villegas JA   +13 more
europepmc   +1 more source

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