Results 11 to 20 of about 527,379 (343)

Epithelial-derived interleukin-23 promotes oral mucosal immunopathology. [PDF]

Immunity
At mucosal surfaces, epithelial cells provide a structural barrier and an immune defense system. However, dysregulated epithelial responses can contribute to disease states. Here, we demonstrated that epithelial cell-intrinsic production of interleukin-23 (IL-23) triggers an inflammatory loop in the prevalent oral disease periodontitis.
Kim TS, Ikeuchi T, Theofilou VI, Williams DW, Greenwell-Wild T, June A, Adade EE, Li L, Abusleme L, Dutzan N, Yuan Y, Brenchley L, Bouladoux N, Sakamachi Y, NIDCD/NIDCR Genomics and Computational Biology Core, Palmer RJ, Iglesias-Bartolome R, Trinchieri G, Garantziotis S, Belkaid Y, Valm AM, Diaz PI, Holland SM, Moutsopoulos NM.   +23 more
europepmc   +3 more sources

A Genome-Wide Association Study Identifying Novel Genetic Markers of Response to Treatment with Interleukin-23 Inhibitors in Psoriasis. [PDF]

Genes (Basel)
Zachari S, Liadaki K, Planaki A, Zafiriou E, Kouvarou O, Gerogianni K, Giannoulis T, Mamuris Z, Bogdanos DP, Moschonas NK, Sarafidou T.   +10 more
europepmc   +3 more sources

Interleukin-20 Gene Polymorphism and Serum Levels of Interleukin-20 and Interleukin-23 in Rheumatoid Arthritis

Diyala Journal of Medicine
Background: Rheumatoid arthritis (RA) is an autoimmune disease marked by complex causes and ongoing joint inflammation. Recently, more efforts have been directed at finding new non-invasive prognostic biomarkers for RA, which can help in disease ...
Iman Najat Ali, Najat Jabbar Ahmed Berwary   +1 more
doaj   +3 more sources

Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification

Applied Sciences, 2022
Background: Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of periodontium support tissue generated by different immuno-inflammatory mechanisms, including the RANK/RANKL/OPG and the IL-23/IL-17 axis.
Ruth Rodríguez-Montaño, Alondra del Carmen Ruiz-Gutiérrez, Vianeth María del Carmen Martínez-Rodríguez, Juan Ramón Gómez-Sandoval, Juan Manuel Guzmán-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velázquez   +7 more
doaj   +1 more source

Lichen planus onset during interleukin 23 blockade for treatment of psoriasis [PDF]

JAAD Case Reports
Alia Abbas, MD, Andrew Schroeder, PhD, Carly Elston, MD, Chander Raman, PhD, Boni Elewski, MD   +4 more
doaj   +2 more sources

Circulating Interleukin-23 Levels in Rheumatoid Arthritis and its Relationship to Disease Activity: a Systematic Review with Meta-Analysis

مجله كليه طب الكندي, 2023
Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam, Shaza Abdul Basset Abdul Basset, Heba Khaled, Neveen Refaey, Ahmed Atta Ahmed Ali, Saad abdelrahim saad shoulah, Mohammed Saleh Al Saifi, Mahmoud s.Meleha   +7 more
doaj   +1 more source

Prospects for the use of monoclonal antibodies to interleukin 23 Gusеlkumab in psoriatic arthritis: New data

Научно-практическая ревматология, 2022
Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov, T. V. Korotaeva, S. Rodolfi, C. F. Selmi   +3 more
doaj   +1 more source

Interleukin 23 in Crohnʼs Disease [PDF]

Inflammatory Bowel Diseases, 2014
: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in genome-wide association studies ...
Oukka, Mohamed, Eken, Ahmet, Singh, Akhilesh K.   +2 more
openaire   +3 more sources

Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities

Cells, 2020
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis, or rheumatoid arthritis.
Gloria Pastor-Fernández, Isabel R. Mariblanca, María N. Navarro   +2 more
doaj   +1 more source

Current concepts in the pathogenesis of spondyloarthritis

Indian Journal of Rheumatology, 2020
Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us ...
Nibha Jain, Arumugam Moorthy
doaj   +1 more source