Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?
Frontiers in Neurology, 2021 Neuronal cell death, amyloid β plaque formation and development of neurofibrillary tangles are among the characteristics of Alzheimer's disease (AD). In addition to neurodegeneration, inflammatory processes such as activation of microglia and astrocytes ...
Louisa Nitsch +3 more
doaj +1 more source
Journal of Investigative Surgery, 2021 Background Idiopathic Granulomatous Mastitis (IGM) is a benign chronic inflammatory breast disease that mimics breast cancer, and the etiopathogenesis has not yet been fully evaluated. Autoimmunity has received the most focus as a possible etiology.
Mehmet Saydam +8 more
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Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression [PDF]
, 2012 published_or_final_versio
Chen, L +7 more
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Progress in spondylarthritis immunopathogenesis of spondyloarthritis: which cells drive disease? [PDF]
, 2009 Spondyloarthritides, or SpA, form a cluster of chronic inflammatory diseases with the axial skeleton as the most typical disease localisation, although extra-articular manifestations such as intestinal inflammation may frequently occur during the course ...
Melis, Lode, Elewaut, Dirk
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Risk of Cutaneous T Cell Lymphoma with Psoriasis Biologic Therapies
Dermatology and Therapy, 2023 Background The risk of developing cutaneous T cell lymphoma (CTCL) in patients using psoriasis biologics has not been well characterized. The goals of this review were to investigate the incidence of CTCL in patients with psoriasis receiving biologic ...
Mitchell S. Davis +7 more
doaj +1 more source
The Role of Interleukin-17 in Juvenile Idiopathic Arthritis: From Pathogenesis to Treatment
Medicina, 2022 Background and Objectives: Interleukin-17 (IL-17) is a cytokine family consisting of six members and five specific receptors. IL-17A was the first member to be identified in 1993.
Marino Paroli +5 more
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Gram-positive pathogenic bacteria induce a common early response in human monocytes [PDF]
, 2010 Background We infected freshly isolated human peripheral monocytes with live bacteria of three clinically important gram-positive bacterial species, Staphylococcus aureus, Streptococcus pneumoniae and Listeria monocytogenes and studied the ensuing early ...
Svetlin Tchatalbachev +3 more
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INTERLEUKIN -23, APPLICATION PROSPECTS (LITERATURE REVIEW)
Eurasian Journal of Medical and Natural Sciences, 2023 With the advent of new technologies, several new pro-inflammatory cytokines have been characterized, such as IL-23, which plays an important role in the pathogenesis of a number of inflammatory diseases. IL-23 pathways, as well as other proteins involved in the pathogenesis of inflammatory diseases, are currently under development and show promising ...
H.B. Mahamathojayeva +3 more
openaire +2 more sources
Nociceptive Sensory Neurons Drive Interleukin-23 Mediated Psoriasiform Skin Inflammation [PDF]
, 2015 The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbors specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17 ...
Alvarez, David +7 more
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Interleukin 23 in the skin: role in psoriasis pathogenesis and selective interleukin 23 blockade as treatment [PDF]
Therapeutic Advances in Chronic Disease, 2018 Plaque psoriasis is one of the most common autoimmune skin diseases and is characterized by erythematous, scaly plaques. Many highly effective, targeted therapies have been developed as a result of an improved understanding of the pathogenesis of psoriasis. Using agents that target the central interleukin (IL)-23/IL-17 immune axis, this once difficult-
Tom C, Chan +2 more
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