Results 51 to 60 of about 19,069,468 (280)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

Frontiers in Cellular Neuroscience, 2014
Chronic inflammation and oxidative stress (OS) are present in Alzheimer´s disease (AD) brains in addition to neuronal loss, Amyloid-β (Aβ) plaques and hyperphosphorylated tau-protein neurofibrillary tangles.
Elina M Sutinen, Elina M Sutinen, Minna A Korolainen, Jukka eHäyrinen, Irina eAlafuzoff, Steven ePetratos, Antero eSalminen, Hilkka eSoininen, Hilkka eSoininen, Hilkka eSoininen, Tuula ePirttilä, Johanna O Ojala, Johanna O Ojala   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame [PDF]

, 2012
Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway.
Martin Michaelis, Muster Thomas, Joachim Seipelt, Markus Wolschek (167359), Martin Michaelis (23843), Marijke van Rikxoort (167355), Doerr, Hans Wilhelm, Wolschek Markus, Seipelt Joachim, Hans Wilhelm Doerr (17928), Andrej Egorov (167364), Thomas Muster, Hans Wilhelm Doerr, Jindrich Cinatl, Thomas Muster (167361), Muster, Thomas, Doerr Hans Wilhelm, Seipelt, Joachim, Joachim Seipelt (30928), Egorov Andrej, Cinatl Jindrich, Michaelis, Martin, Cinatl, Jindrich, Egorov, Andrej, Markus Wolschek, van Rikxoort, Marijke, Rikxoort, Marijke van, Andrej Egorov, van Rikxoort Marijke, Jindrich Cinatl Jr (167368), Wolschek, Markus, Marijke van Rikxoort, Michaelis Martin   +32 more
core   +2 more sources

Interleukin-6 levels in the control and AAA groups.

, 2023
There was no significant difference in plasma levels of IL-6 between groups (P = .17). AAA, abdominal aortic aneurysm; IL-6, interleukin-6.
Lenka Maliskova (8781746), Robert L. Raffai (12633072), Shant M. Vartanian (14614693), Adam Z. Oskowitz (14614696), Andrea J. Barczak (782932), Laura Bouchareychas (3493793), Michael S. Conte (12160976), Joshua D. Rudolph (14614690), Phat Duong (5718677), Jose L. Lopez (14614678), Tuan Anh Phu (14614684), Christina R. Kuhrau (14614687), Pei-Yu Lin (3370841), Walter L. Eckalbar (9243670), Joel L. Ramirez (14614681)   +14 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of Periwinkle Extract (Catharanthus roseus) on Caspase-3 Levels and Renal Interleukin-6 Levels on Cadmium Poisoning

Jurnal Teknologi Laboratorium
Cadmium is a toxic heavy metal known to induce oxidative stress, DNA damage, and inflammation, particularly in kidney tissue, as shown by elevated levels of inflammatory cytokines such as Interleukin-6 (IL-6) and apoptotic markers like Caspase-3.
Qisthy Kurrota Aini, Agung Putra, Chodidjah   +2 more
doaj   +1 more source

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Acta Stomatologica Croatica, 2020
Objective: The aim of this study was to investigate whether genetic susceptibility to chronic peri-odontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal ...
Georgios S. Chatzopoulos, Aikaterini-Elisavet Doufexi, Sofia Zarenti, Menelaos Anastasopoulos, Anastasia Kouvatsi   +4 more
doaj   +1 more source

Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway

, 2002
Granulomatous Diseases Review Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production ...
Kumararatne, D.S., Baretto, Richard, De Heer, E., J.F. EMILE, Ottenhoff, THM, De Heer, E, Edgar, JD, Binch, J., Ottenhoff, T.H., Casanova, J.L., Lammas, David, Lammas, D.A., Edgar, J, Kumararatne, DS, Panchalingam, S, Novelli, V., E. DE HEER, Drysdale, P, Binch, J, Ottenhoff, TH, Panchalingam, S., Emile, JF, Drysdale, Pamela, C. MACLENNAN, T. H. M. OTTENHOFF, Ben-smith, Anne, Novelli, V, P. DRYSDALE, MacLennan, Calman, R. BARETTO, Casanova, JL, J. BINCH, Ben-Smith, A., Casanova, J-L, Ben-Smith, A, Drysdale, P., Emile, J.F., D. S. KUMARARATNE, Baretto, R, Baretto, R., S. PANCHALINGAM, J.-L. CASANOVA, MacLennan, C, J. D. EDGAR, A. BEN-SMITH, Kumararatne, Dinakantha, D. A. LAMMAS, MacLennan, C., Lammas, David A, V. NOVELLI   +49 more
core   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, de Waal-Malefyt, R., Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +39 more
core   +1 more source