Results 121 to 130 of about 2,200,720 (269)

A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression [PDF]

, 2016
Itch, the unpleasant sensation that elicits a desire to scratch, is mediated by specific subtypes of cutaneous sensory neuron. Here, we identify a subpopulation of itch-sensing neurons based on their expression of the receptor tyrosine kinase Ret.
Bilbao, Daniel, Castaldi, Laura, De Castro Reis, Fernanda, Dhandapani, Rahul, Heppenstall, Paul A, Iovino, Loredana, Martinez, Concepcion, Nocchi, Linda, Paparountas, Triantafillos, Perlas, Emerald, Pesaresi, Martina, Portulano, Carla, Shirlekar, Kalyanee S, Stantcheva, Kalina K   +13 more
core   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain

Mediators of Inflammation, 2007
Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study.
Qianming Chen, Juan Xia, Mei Lin, Hongmei Zhou, Bingqi Li   +4 more
doaj   +1 more source

Effect of immobilization stress on scratching behavior in male rat [PDF]

, 2011
زمینه و هدف: استرس یکی از بزرگترین مشکلات روانی بوده و زمینه ساز بسیاری از مشکلات سلامتی از جمله بیماری های عروقی قلب، مغز، سرطان ها و تضعیف ایمنی می باشد.
Allahtavakoli, Mohammad., Amin, Fatemeh., Arab Baniassad, Fatemeh., Baniassad, Shima.   +3 more
core  

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

The first trial of CIM331, a humanized antihuman interleukin‐31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double‐blind, placebo‐controlled study

British Journal of Dermatology, 2016
The cytokine interleukin‐31 (IL‐31) is considered to be responsible for the development of pruritus in humans. At present, no available evidence has been provided on the safety and efficacy of blocking the IL‐31 signal in humans for the amelioration of ...
Osamu Nemoto, Masutaka Furue, Hidemi Nakagawa, M. Shiramoto, R. Hanada, S. Matsuki, S. Imayama, Mayumi Kato, I. Hasebe, K. Taira, M. Yamamoto, R. Mihara, Kenji Kabashima, T. Ruzicka, Jon M. Hanifin, Y. Kumagai   +15 more
semanticscholar   +1 more source

An anatomic gene expression atlas of the adult mouse brain [PDF]

, 2009
Studying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scale in situ hybridization datasets enables new possibilities for understanding brain organization ...
A Alvarez-Buylla, A MacKenzie-Graham, A MacKenzie-Graham, A Visel, Allan R Jones, Amy Bernard, AW Toga, AW Toga, Caroline C Overly, CE Gee, Chihchau Kuan, Chinh Dang, Chris Lau, David J Anderson, DC Van Essen, DN Abrous, Ed S Lein, ES Lein, G Marini, G Paxinos, Hemant Bokil, Hong-Wei Dong, HW Dong, Jason W Bohland, JB Kruskal, JB Kruskal, JL Price, John Hohmann, K Brodmann, LL Ng, Luis Puelles, LW Swanson, Lydia Ng, MA Zapala, MH DeGroot, Michael Hawrylycz, N Flames, P Voorn, PA Yushkevich, Partha P Mitra, RF Bonner, Sayan Pathak, SM Sherman, SM Sunkin, Susan M Sunkin, T Yamamori, VB Mountcastle, Y Ma, Y Nakamura   +48 more
core   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Mediators of Pruritus in Psoriasis [PDF]

, 2007
The pathogenesis of pruritus in psoriasis remains unclear. Many possible mediators were implicated to transmit or modulate this sensation in psoriasis, but none has been clearly proven to be a causative agent of itching.
Reich, Adam, Szepietowski, Jacek C.
core   +4 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source