Results 231 to 240 of about 56,984,652 (272)
Advanced Science, EarlyView.Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong +9 more
wiley +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Advanced Science, EarlyView.High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang +11 more
wiley +1 more source
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Rheumatology International, 2016
Interleukin-31 (IL-31) is the most recently discovered member of the gp130/IL-6 cytokine family which is produced mainly by activated Th2 cells. IL-31 was proved to play a crucial role in autoimmune and inflammatory diseases such as atopic dermatitis, asthma, cutaneous T cell lymphomas, Kawasaki disease and allergic rhinitis.
Hua-Tuo, Huang +4 more
openaire +2 more sources
Interleukin-31 (IL-31) is the most recently discovered member of the gp130/IL-6 cytokine family which is produced mainly by activated Th2 cells. IL-31 was proved to play a crucial role in autoimmune and inflammatory diseases such as atopic dermatitis, asthma, cutaneous T cell lymphomas, Kawasaki disease and allergic rhinitis.
Hua-Tuo, Huang +4 more
openaire +2 more sources
Anti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
New England Journal of Medicine, 2017Interleukin-31 may play a role in the pathobiologic mechanism of atopic dermatitis and pruritus. We wanted to assess the efficacy and safety of nemolizumab (CIM331), a humanized antibody against interleukin-31 receptor A, in the treatment of atopic dermatitis.In this phase 2, randomized, double-blind, placebo-controlled, 12-week trial, we assigned ...
Alexander, Egeberg +2 more
openaire +6 more sources
Interleukin 31 is involved in intrahepatic cholestasis of pregnancy
The Journal of Maternal-Fetal & Neonatal Medicine, 2016Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder characterized by maternal itching and altered liver function. Interleukin (IL)-31 is known to be involved in the pathogenesis of pruritic inflammatory skin diseases. In a three-year period, 13 women with a singleton pregnancy and a diagnosis of intrahepatic cholestasis (ICP) were enrolled ...
BASILE, FRANCESCA +6 more
openaire +3 more sources
Interleukin 31 and skin diseases: A systematic review
Allergy and Asthma Proceedings, 2017Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus.
Gangemi, Sebastiano +5 more
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Interleukin 31 in vitiligo patients with and without pruritus
Acta Dermatovenerologica Alpina Pannonica et AdriaticaVitiligo is a prevalent skin disorder characterized by the destruction of melanocytes, leading to depigmented patches across various areas of the body. Interleukin (IL)-31 has been implicated in the development of pruritus and skin inflammation, potentially contributing to cutaneous symptoms.
Shaimaa E, Lashin +4 more
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The Role of Interleukin-31 in Atopic Dermatitis of Iraqi Patients
2022Abstract The study was set up to investigate the role of Interleukin-31 (IL-31) in atopic dermatitis. IL-31 is a member of the innate immune system, it is preferentially expressed by Th2 cells, and is highly recognized in AD skin lesions. Ninety persons from both genders are included in the study, forty-five of them were patients and the same number ...
Amel A. Naji, Hind M. Mousa
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