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Interleukin 31 is involved in intrahepatic cholestasis of pregnancy
The Journal of Maternal-Fetal & Neonatal Medicine, 2016Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder characterized by maternal itching and altered liver function. Interleukin (IL)-31 is known to be involved in the pathogenesis of pruritic inflammatory skin diseases. In a three-year period, 13 women with a singleton pregnancy and a diagnosis of intrahepatic cholestasis (ICP) were enrolled ...
BASILE, FRANCESCA +6 more
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Interleukin 31 and skin diseases: A systematic review
Allergy and Asthma Proceedings, 2017Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus.
Gangemi, Sebastiano +5 more
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Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases
Current Allergy and Asthma Reports, 2014Interleukin-31 (IL-31) is a newly discovered cytokine associated with chronic skin inflammation and pruritus. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin ...
Rabenhorst, Anja, Hartmann, Karin
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Interleukin 31 in vitiligo patients with and without pruritus
Acta Dermatovenerologica Alpina Pannonica et AdriaticaVitiligo is a prevalent skin disorder characterized by the destruction of melanocytes, leading to depigmented patches across various areas of the body. Interleukin (IL)-31 has been implicated in the development of pruritus and skin inflammation, potentially contributing to cutaneous symptoms.
Shaimaa E, Lashin +4 more
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The Role of Interleukin-31 in Atopic Dermatitis of Iraqi Patients
2022Abstract The study was set up to investigate the role of Interleukin-31 (IL-31) in atopic dermatitis. IL-31 is a member of the innate immune system, it is preferentially expressed by Th2 cells, and is highly recognized in AD skin lesions. Ninety persons from both genders are included in the study, forty-five of them were patients and the same number ...
Amel A. Naji, Hind M. Mousa
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Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis
Journal of the American Academy of Dermatology, 2014Interleukin (IL)-31 induces severe pruritus and dermatitis in transgenic mice, and is associated with many itching skin diseases.We sought to investigate the association of serum IL-31 levels with uremic pruritus in patients undergoing hemodialysis.Patients receiving maintenance hemodialysis in a referral medical center were recruited.
Mei-Ju, Ko +9 more
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Current Treatment Options in Allergy, 2018
Atopic dermatitis (AD) is a chronic eczematous skin disease associated with intense pruritus and skin barrier dysfunction. Interleukin-31 (IL-31), which is preferentially produced by T helper 2 (Th2) cells, has attracted attention as a pruritogen in patients with AD.
Takeshi Nakahara, Masutaka Furue
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Atopic dermatitis (AD) is a chronic eczematous skin disease associated with intense pruritus and skin barrier dysfunction. Interleukin-31 (IL-31), which is preferentially produced by T helper 2 (Th2) cells, has attracted attention as a pruritogen in patients with AD.
Takeshi Nakahara, Masutaka Furue
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Immunohistochemical study of interleukin-31 in patients with atopic dermatitis
Egyptian Journal of Dermatology and Venereology, 2018Background Atopic dermatitis (AD) is a common chronic inflammatory skin disease of unknown etiology. Reduction of pruritus as one of the hallmarks of AD is the most effective therapeutic strategy for improving quality of life and for preventing aggravation of skin lesion. Interleukin-31 (IL-31) has been suggested to play a role
Tarek E. Amin +2 more
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A systematic review of interleukin-31 inhibitors in the treatment of prurigo nodularis
InflammopharmacologyPrurigo nodularis (PN) is a neuroimmunological skin disease. Severe itching is the most challenging symptom which affects patients' quality of life. T helper 2-derived cytokines, such as interleukin-31 and oncostatin M (OSM), play a crucial role in PN pathogenesis. Nemolizumab and vixarelimab are two biologics acting as IL-31 inhibitors.
Mohammad Ali Nilforoushzadeh +9 more
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